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抑制剂描述:
产品名称:BIX-01294
产品别名:N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
英文别名:BIX 01294;BIX01294;BIX-01294
靶点:G9a
CAS:935693-62-2
纯度:>98%
外观:Off-white solid
保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.
描述:
BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM.
溶解性:H2O : 14.29 mg/mL (29.13 mM; Need ultrasonic)
体外研究:
BIX-01294 (4.1 μM) treatment of G9anull ES cells results in a further reduction in H3K9me2 levels. BIX-01294 reduces H3K9me2 at several G9a target genes. BIX-01294 (5 µM) reduces levels of global H3K9 methylation in pronuclear- and 2-cell-stage embryos. Embryos transiently exposed to BIX-01294 have a reduced ability to establish pregnancy. BIX-01294 (1 µg/mL) causes reduction in the BrdU incorporation of fetal PASMCs. BIX-01294 treatment decreases the PASMCs migration induced by PDGF.
体内研究:
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