PP 2; AG1879; AG 1879,AGL 1879

PP 2; AG1879; AG 1879,AGL 1879,PP2; AG1879; AG 1879,AGL 1879
  • PP 2; AG1879; AG 1879,AGL 1879,PP2; AG1879; AG 1879,AGL 1879
  • CAS号172889-27-9
  • 中文名称PP 2; AG1879; AG 1879,AGL 1879
  • 英文名称PP2; AG1879; AG 1879,AGL 1879
  • 发布时间2021/9/26 15:52:52

产品属性

  • 产品名称: PP 2; AG1879; AG 1879,AGL 1879
  • 产品英文名称: PP2; AG1879; AG 1879,AGL 1879
  • 包装价格: 5mg/866RMB;50mg/3153RMB
  • 纯度规格: >98%
  • 产品类别: 激动剂抑制剂
2021/9/26 15:52:52 PP 2; AG1879; AG 1879,AGL 1879 PP2; AG1879; AG 1879,AGL 1879 5mg/866RMB;50mg/3153RMB 866 >98% 激动剂抑制剂

产品描述

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抑制剂描述:

产品名称:PP2

产品别名:伐地考昔

英文别名:PP 2;AG1879;AG 1879;AGL 1879

靶点:LCK ,Fyn

CAS:172889-27-9

 

纯度:>98%

外观:Powder

保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述:

PP2 is Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA.

 

溶解性:DMSO :60 mg/mL (198.82 mM)
Ethanol:2 mg/mL (6.62 mM)

体外研究:

PP2 inhibits Src by binding to an area of the molecule that does not overlap with the ATP binding domain. PP2 (20 μM) induces 40-50% growth inhibition of HT29 cells, this concentration reduces the Src activity as early as 1 hour and maintains a 35% inhibition of Src activity for 2 days. PP2 (100 mM) decreases the Src activity of HT29 cells in a dose-dependent manner. PP2 (1 mM-100 mM) causes a dose-dependent growth inhibition of human colon cancer cells (HT29, SW480, and PMCO1), liver cancer cells (PLC/PRF/5, KYN-2, Li7, and HepG2), and breast cancer cells (MCF-7, MDA-MB-468, and BT-474). PP2 (20 μM) significantly increases aggregation in most of the cancer cells (HT29, SW480, PMCO1, PLC/PRF/5, KYN-2, Li7, MCF-7, and MDA-MB-468) in E-cadherin dependent manner. PP2 (20 μM) enhances E-cadherin expression and also strongly increases E-cadherin’s association with the actin cytoskeleton in cancer cells. PP2 (20 μM) increases the expression of α-catenin, β-catenin, and γ-catenin in HT29 cells, whereas in PLC/PRF/5 and MCF-7 cells, the total protein level of α-catenin does not change, but the levels of β- catenin and γ-catenin increases slightly. PP2 inhibits proliferation of two cervical cancer cells (HeLa and SiHa) in a time- and dose-dependent manner. PP2 (10 μM) down-regulates pSrc-Y416, pEGFR-Y845, and -Y1173 expression levels in HeLa and SiHa cells. PP2 (10 μM) could modulate cell cycle arrest by up-regulating p21(Cip1) and p27(Kip1) in both HeLa and SiHa cells and down-regulating expression of cyclin A, and cyclin dependent kinase-2, -4 (Cdk-2, -4) in HeLa and of cyclin B and Cdk-2 in SiHa.

 

体内研究:PP2 (5 mg/kg/day) induces some slowing in the growth rate of the primary tumors relative to the control treated with vehicle in SCID mice inoculated HT29 cells in the spleen. PP2 (5 mg/kg/day) induces some slowing in the growth rate of the primary tumors relative to the control treated with vehicle in SCID mice inoculated HT29 cells in the spleen. PP2 (5 mg/kg/day) significantly reduces the relative liver weight and liver metastasis volume compared with the controls in SCID mice inoculated HT29 cells in the spleen. PP2 (1.5 mg/kg i.p.) treated rats show approximately 50% reduction of infarct size on T2-weighted MRI and in TTC staining compared with controls in rats with focal ischemic brain injury. PP2 (1.5 mg/kg i.p.) results in better the neurological score than controls in rats with focal ischemic brain injury.

 

产品信息订购:

  产品货号
  产品名称
  规格
价格
大包装及货期
  abs810398
  PP2
  5mg
  825
  立即咨询

产品更多信息请进入爱必信网站咨询

关键字: PP2; AG1879; AG 1879,AGL 1879

公司简介

爱必信(上海)生物科技有限公司成立于2010年,位于上海市申江科创园。是一家自主研发和生产生物试剂的公司。 Absin?是爱必信(上海)生物科技有限公司的试剂品牌,目前已近60万种生化试剂,10万种抗体,其基础生化试剂在基础科学领域得到广泛应用的同时,特色产品线常规生化试剂,血清,小分子激动剂及抑制剂在业界也备受好评。 Absin秉承踏实,务实,求精和不断创新的精神为中国科学家提供最好的产品,努力打造属于中国自己的生物试剂品牌,为广大科学家提供更全面更丰富更优质的产品。 爱科研,必信它(Absin)!Absin努力成为你身边的科研百宝箱!

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