网站主页 > 化工产品目录 > 生物化工 > 抑制剂 > PI3K/Akt/mTOR抑制剂(PI3K/Akt/mTOR) > PI3K 抑制剂 > BKM120 (NVP-BKM120, Buparlisib) > NVP-BKM120(Buparlisib)

NVP-BKM120(Buparlisib)

NVP-BKM120(Buparlisib),NVP-BKM-120, BKM-120; Buparlisib; BKM120; BKM 120
  • NVP-BKM120(Buparlisib),NVP-BKM-120, BKM-120; Buparlisib; BKM120; BKM 120
  • 产品价格:¥831
  • 中文名称:NVP-BKM120(Buparlisib)
  • 英文名称:NVP-BKM-120, BKM-120; Buparlisib; BKM120; BKM 120
  • CAS:944396-07-0
  • 发布时间:2020/3/31 10:22:57
委托采购
联系方式
  • 爱必信(上海) 生物科技有限公司 | 点击这里给我发消息
  • 会员等级: 企业会员 1年 | 上海市浦东新区新浩路58号18号楼
  • 产品描述
  • 公司简介

产品属性:

  • 产品名称: NVP-BKM120(Buparlisib)
  • 产品英文名称: NVP-BKM-120, BKM-120; Buparlisib; BKM120; BKM 120
  • 包装价格: 5mg/831RMB;50mg/3030RMB
  • 纯度规格: >98%
  • 产品类别: 激动剂抑制剂
发布时间: 2020/3/31 10:22:57 产品名称: NVP-BKM120(Buparlisib) 产品英文名称: NVP-BKM-120, BKM-120; Buparlisib; BKM120; BKM 120
CAS号: 产品包装: 5mg/831RMB;50mg/3030RMB 产品价格: 831RMB
有效期: 品牌: 产地:
保存条件: 纯度规格: >98% 产品类别: 激动剂抑制剂

产品描述:

公告提醒:爱必信所有产品和服务仅用于科学研究不用于临床应用及其他用途提供产品和服务也不为任何个人提供产品和服务)!

 

抑制剂描述:

产品名称:NVP-BKM120(Buparlisib)

产品别名:布帕尼西

英文别名:NVP-BKM-120;BKM-120;Buparlisib;BKM120;BKM 120

靶点:p110α ,p110δ ,p110β ,p110γ ,Vps34

CAS:944396-07-0

 

纯度:>98%

外观:Powder

保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述:

BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ.

 

溶解性:DMSO :76 mg/mL (185.2 mM)
Ethanol:2 mg/mL (4.87 mM)

体外研究:

BKM120 is not sensitive to Class III and Class IV PI3K's or PI4K. NVP-BKM120 shows great antiproliferation activity to PI3K deregulated cell lines including A2780, U87MG, MCF7 and DU145 with GI50 of 0.1-0.7 nM. BKM120 induces multiple myeloma cells (ARP1, ARK, MM.1S, MM1.R and U266) apoptosis, which results in increased G1-phase cells and decreased S-phase cells. BKM120 induced CD138+ primary MM cell apoptosis and has significant lower cytotoxicity toward CD138− stromal cells. BKM120 exposure could cause upregulation of BimS and downregulation of XIAP. BKM120 demonstrates antiproliferative activity in human gastric cancer cell lines by decreasing mTOR downstream signaling. BKM120 could increase either p-ERK or p-STAT3 in KRAS mutant gastric cancer cells. Combination with STAT3 blockade, BKM120 shows a synergism in cells harboring mutated KRAS by inducing apoptosis, but not in KRAS wild-type cells. A recent study shows that BKM120 shows differential forms of cell death on the basis of p53 status of the cells with p53 wild-type cells undergoing apoptotic cell death and p53 mutant/deleted cells having a mitotic catastrophe cell death. BKM120 mediates mitotic catastrophe mainly through Aurora B kinase.

 

体内研究:BKM120 completely inhibits pAktser473 in A2780 xenograft tumors at doses of 30, 60, or 100 mg/kg, respectively. BKM120 also shows antitumor activity against U87MG glioma model at doses of 30 and 60 mg/kg. BKM120 treatment results in significantly reduced tumor volume and level of circulating human kappa chain at 5 μM/kg/day−1in ARP1 SCID mouse model, with prolonged survival.

 

产品信息订购:

  产品货号
  产品名称
  规格
价格
大包装及货期
  abs810586
  NVP-BKM120(Buparlisib)
  5mg
  791
  立即咨询

产品更多信息请进入爱必信网站咨询

关键字:NVP-BKM-120, BKM-120; Buparlisib; BKM120; BKM 120

供应商联系方式:

  • 联系人: 周小姐
  • 公司名称: 爱必信(上海) 生物科技有限公司
  • 电话:021-38015121
  • 手机: 15502157206
  • 传真 :
  • 邮箱 :info@absin.cn
  • 地址 : 上海市浦东新区新浩路58号18号楼

公司简介:

爱必信(上海)生物科技有限公司成立于2010年,位于上海市申江科创园。是一家自主研发和生产生物试剂的公司。 Absin?是爱必信(上海)生物科技有限公司的试剂品牌,目前已近60万种生化试剂,10万种抗体,其基础生化试剂在基础科学领域得到广泛应用的同时,特色产品线常规生化试剂,血清,小分子激动剂及抑制剂在业界也备受好评。 Absin秉承踏实,务实,求精和不断创新的精神为中国科学家提供最好的产品,努力打造属于中国自己的生物试剂品牌,为广大科学家提供更全面更丰富更优质的产品。 爱科研,必信它(Absin)!Absin努力成为你身边的科研百宝箱!

BKM120 (NVP-BKM120, Buparlisib) 生产厂家及价格列表: 更多

产品名称 价格 公司名称 发布日期
NVP-BKM120(Buparlisib) ¥831 爱必信(上海) 生物科技有限公司 [2020/03/31]
BKM120 (NVP-BKM120,Buparlisib) ¥1200 南京百鑫德诺生物科技有限公司 [2020/03/30]
布帕尼西 询价 麻城市进鑫生物科技有限公司 [2019/06/10]
BKM120 ¥10 湖北紫樱花化工有限公司(销售部分部) [2019/03/14]
BKM120原料药哪里有卖 ¥10 湖北紫樱花化工有限公司 [2018/11/06]
BKM120 ¥350 湖北帝柏化工有限公司 [2016/12/15]
BKM120原料 ¥200 湖北帝柏化工有限公司 [2016/09/22]
BKM120原料 ¥60 湖北帝柏化工有限公司 [2016/08/17]
BKM120全新包装小分子靶向药效果价格 ¥300 武汉帝康医药原料有限公司 [2016/08/05]
BKM120,944396-07-0,专业科研原料药 ¥1 湖北盛天恒创生物科技有限公司原料部 [2016/07/25]


供应商其他产品:

新生牛血清(标准级)Anti- His Tag抗体增强型BCA蛋白定量试剂盒
Anti- Myc 抗体马血清(优级)胎牛血清(标准级)
BCA蛋白定量试剂盒澳洲新生牛血清马血清(标准级)
他克莫司,FK-506; Fujimycin; FR900506; FK506; FK 506 Programmed cell death 1 ligand 1/PD-L1 proteinRabbit anti-Goat IgG-HRP
SHP-099盐酸盐Goat anti-Mouse IgG-FITCHuman IL-12 p70 ELISA Kit
BIX-0129410×PBS缓冲液Anti-V5,mAb抗体
SB-431542WIN552122,WIN-552122,(R)-(+)-WIN 55212Human IFN-gamma ELISA Kit
Mouse IL-6 ELISA KITS3I-201Human IL-23 ELISA Kit
Mouse TNF alpha ELISA KitGoat anti-Rabbit IgG-AlexaFluor 488Human IL-6 ELISA Kit
Human EGF ELISA KitHuman PD-L1/B7-H1 ELISA KIT盐酸可乐定
Anti- HA 抗体Human IL-1 beta ELISA kitHuman IL-1 beta ELISA kit
Rat IL-6 ELISA KitDL 15000 DNA MarkerHis(C-terminal Specific) 小鼠单克隆抗体
甲基泼尼松龙;甲泼尼龙Human PD-1 ELISA KITHuman MMP-9 ELISA Kit
Mouse IL-1 beta ELISA KITMouse VEGF ELISA KitApatinib; YN968D1
Epacadostat (INCB024360)FH 535; FH-535PP 2; AG1879; AG 1879,AGL 1879
LBH-589(Panobinostat)LEE 011; LEE-011,Ribociclib,LEE011PSI-7977,GS-7977,PSI 7977,GS 7977,sofosbuvir
ThiazovivinNVP-BKM120(Buparlisib)Ertapenem;厄他培南
Rivaroxaban; BAY 59-7939INT-747(Obeticholic acid)PD0332991(free base)
TirofibanNSC 123127;Adriamycin; Hydroxydaunorubicin hydrochloride;Bay 43-9006,Bay43-9006
JQ-1,JQ 1,JQ1,+JQ 1,+JQ-1,+JQ1BML-284; 2-Amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl)pyrimidineVorinostat (SAHA)
Apatinib Mesylate;YN968D1Captopril;A333;甲巯丙脯酸胆固醇
GAPDH 小鼠单克隆抗体β-tubulin 小鼠单克隆抗体human IL2 重组蛋白; T-cell growth factor;TCGF
Collagen I Antibodyanti-Mouse IgG-FITC;IgG-FITC抗体Mouse IL-12 p70 ELISA KIT
MC1568;MC 1568;MC-1568IWP-2;ABC 294640;ABC-294640ABT199;GDC0199;ABT 199;GDC 0199;GDC-0199;Venetoclax
Tretinoin;All-trans Retinoic AcidRW22164;RWJ22164二甲基亚砜(DMSO)(AR级)
Rabbit anti-TLR4 Polyclonal Antibodybeta I Tubulin AntibodyTubulin alpha Antibody
Goat anti-Rabbit IgG-FITCGoat anti-Rabbit IgG-Cy3二硫苏糖醇(DTT);1,4二巯基苏糖醇
Human TNF-α ELISA KitHuman VEGF ELISA KitMouse IL-2 ELISA KIT
Mouse IL-4 ELISA KITHuman IL-2 ELISA KitHuman IL-10 ELISA Kit
DL 5000 DNA MarkerXAV939;NVP-XAV 939Capecitabine
Benzatropine mesylate; Benzotropine mesylate;Benztropine methanesulfonate;甲磺酸苯扎托品替米沙坦SCH 13521;Flutamide
Prostaglandin E1;PGE1Cordycepin;3'-DeoxyadenosineImatinib;STI571
组织/细胞裂解液 (多因子检测)ERBB2 AntibodyBAP31 Antibody