网站主页 > 化工产品目录 > 生物化工 > 抑制剂 > 蛋白酪氨酸激酶 > 帕布昔利布(palbociclib) > PD0332991(free base)

PD0332991(free base)

PD0332991(free base),PD0332991; PD-0332991; PD 0332991
  • PD0332991(free base),PD0332991; PD-0332991; PD 0332991
  • 产品价格:¥525
  • 中文名称:PD0332991(free base)
  • 英文名称:PD0332991; PD-0332991; PD 0332991
  • CAS:571190-30-2
  • 发布时间:2020/6/2 10:24:02
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  • 产品描述
  • 公司简介

产品属性:

  • 产品名称: PD0332991(free base)
  • 产品英文名称: PD0332991; PD-0332991; PD 0332991
  • 包装价格: 5mg/525RMB;100mg/3150RMB
  • 纯度规格: >98%
  • 产品类别: 激动剂抑制剂
发布时间: 2020/6/2 10:24:02 产品名称: PD0332991(free base) 产品英文名称: PD0332991; PD-0332991; PD 0332991
CAS号: 产品包装: 5mg/525RMB;100mg/3150RMB 产品价格: 525RMB
有效期: 品牌: 产地:
保存条件: 纯度规格: >98% 产品类别: 激动剂抑制剂

产品描述:

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抑制剂描述:

产品名称:PD0332991(free base)

产品别名:帕布昔利布

英文别名:PD0332991;PD-0332991;PD 0332991

靶点:CDK

CAS:571190-30-2

 

纯度:>98%

外观:Powder

保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述:

Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

 

溶解性:Water:30 mg/mL (61.98 mM)
DMSO:3 mg/mL warmed (6.19 mM)

体外研究:

The IC50 of Palbociclib (PD 0332991) for reduction of retinoblastoma (Rb) phosphorylation at Ser780 in MDA-MB-435 breast carcinoma cells is 66 nM. Palbociclib is equally effective at reducing Rb phosphorylation at Ser795 in this tumor with an IC50 of 63 nM, and similar effects on both Ser780 and Ser795 phosphorylation are obtained in the Colo-205 colon carcinoma. The MP-MRT-AN (AN), KP-MRT-RY (RY), G401, and KP-MRT-NS (NS) cell lines are effectively inhibited by Palbociclib (PD) in a concentration-dependent manner in a WST-8 assay. The IC50s are 0.01 µM, 0.01 µM, 0.06 µM, and 0.6 µM, respectively. In contrast, the KP-MRT-YM (YM) cell line is resistant to Palbociclib (IC50>10 µM). The flow cytometry results show that Palbociclib at concentrations between 0 to 1.0 µM induces G1 arrest in the AN, RY, G401 and NS cell lines in a concentration-dependent manner, but has no effect on YM cells. The BrdU incorporation results are consistent with the WST-8 and flow cytometry results: PD reduces BrdU incorporation (indicating G1 arrest) in the AN, RY, G401 and NS cell lines, but not in the YM cell line. Palbociclib, even at a concentration of 0.05 µM, significantly reduces BrdU incorporation in the AN, RY, and G401 cell lines (p.

 

体内研究:Palbociclib (PD 0332991) exhibits significant antitumor efficacy against multiple human tumor xenograft models. In mice bearing Colo-205 colon carcinoma xenografts (p16 deleted), daily p.o. dosing for 14 days with Palbociclib (150 or 75 mg/kg) produces rapid tumor regressions and a corresponding tumor growth delay of ~50 days with >1 log of tumor cell kill at the highest dose tested. At 37.5 mg/kg, the tumor slowly regressed during treatment. Even at doses as low as 12.5 mg/kg, a 13-day growth delay is obtained indicating a 90% inhibition of tumor growth rate. Likewise, robust antitumor activity is seen in the MDA-MB-435 breast carcinoma (p16 deleted) where complete tumor stasis is apparent at 150 mg/kg and some cell kill is evident at the highest dose.

 

产品信息订购:

  产品货号
  产品名称
  规格
价格
大包装及货期
  abs810696
  PD0332991(free base)
  5mg
  500
  立即咨询

产品更多信息请进入爱必信网站咨询

关键字:PD0332991; PD-0332991; PD 0332991

供应商联系方式:

  • 联系人: 郭小姐
  • 公司名称: 爱必信(上海) 生物科技有限公司
  • 电话:021-38015121
  • 手机: 15502157206
  • 传真 :
  • 邮箱 :info@absin.cn
  • 地址 : 上海市浦东新区新浩路58号18号楼

公司简介:

爱必信(上海)生物科技有限公司成立于2010年,位于上海市申江科创园。是一家自主研发和生产生物试剂的公司。 Absin?是爱必信(上海)生物科技有限公司的试剂品牌,目前已近60万种生化试剂,10万种抗体,其基础生化试剂在基础科学领域得到广泛应用的同时,特色产品线常规生化试剂,血清,小分子激动剂及抑制剂在业界也备受好评。 Absin秉承踏实,务实,求精和不断创新的精神为中国科学家提供最好的产品,努力打造属于中国自己的生物试剂品牌,为广大科学家提供更全面更丰富更优质的产品。 爱科研,必信它(Absin)!Absin努力成为你身边的科研百宝箱!

帕布昔利布 生产厂家及价格列表: 更多

产品名称 价格 公司名称 发布日期
帕布昔利布 询价 山东辰熙医药科技有限公司 [2020/06/02]
帕布昔利布 询价 湖北鸿鑫瑞宇精细化工有限公司 [2020/06/02]
帕布昔利布 询价 湖北鸿鑫瑞宇精细化工有限公司 [2020/06/02]
帕布昔利布 询价 山东海沃生物科技有限公司 [2020/06/02]
帕布昔利布 询价 威尔曼医药集团有限公司 [2020/06/02]
帕博西林/帕布昔利布/帕博西尼 ¥385 威尔曼医药集团有限公司 [2020/06/02]
帕博西尼 ¥18 武汉鼎信通药业有限公司 [2020/06/02]
PD0332991(free base) ¥525 爱必信(上海) 生物科技有限公司 [2020/06/02]
帕布昔利布 询价 湖北摩科化学有限公司 [2020/06/02]
帕布昔利布杂质26 询价 湖北摩科化学有限公司 [2020/06/02]


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