BML-284; 2-Amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl)pyrimidine

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抑制剂描述：

产品名称：Wnt agonist 1

产品别名：BML-284; 2-Amino-4-[3,4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl)pyrimidine

英文别名：BML-284;2-Amino-4-[3;4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl)pyrimidine

靶点：Wnt/β-catenin

CAS：853220-52-7

纯度：≥98%

外观：Yellowish sticky solid

保存方法：-20°C

描述：

Wnt Agonist is a cell-permeable pyrimidine compound that acts as, at an IC₅₀ > 60 μM, a potent and selective activator of Wnt signaling. In addition to mimicking the effect of Wnt, Wnt Agonist has also induced β-catenin and T-cell fate-dependent transcriptional activity in HEK-293T cells at an EC₅₀ = 700 nM. When applied to Xenopous embryos Wnt Agonist caused substantial head defects development. Wnt Agonist has also been observed to enhance beta cell expansion in vitro. The compound is beneficial for studying the effects of Wnt pathway due to the activation of Wnt without inhibiting the activity of GSK-3β.

溶解性：Soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), and 100% ethanol (25 mg/ml).

体外研究：

Wnt agonist 1 does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway.

体内研究：In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus embryonic head specification.

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