Recombinant Human VCC-1/CXCL17

Name

Recombinant Human VCC-1/CXCL17 (Recombinant Human VEGF Co-regulated Chemokine 1/CXCL17; rHuVCC-1/CXCL17)；重组人血管内皮生长因子联合调节趋化因子1/CXCL17

Synonyms

CXCL17; DMC; VCC-1; Chemokine (C-X-C Motif) Ligand 17; C-X-C Motif Chemokine 17; Dcip1; Dendritic Cell And Monocyte Chemokine-Like Protein; DMC; UNQ473; VCC1; VCC-1; VEGF Coregulated Chemokine 1; VEGF Co-Regulated Chemokine 1

Purity

>96% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0μg/ml, corresponding to a specific activity of >200IU/mg.

Physical Appearance

Sterile Filtered lyophilized (freeze-dried) liquid-like powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4, with 3% Trehalose.

Endotoxin

Less than 0.1EU/μg of rHuVCC-1/CXCL17 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Chemokines

Background

CXCL17 also named dendritic cell and monocyte chemokine-like protein (DMC) and VEGF co-regulated chemokine 1 (VCC-1), is a small cytokine belonging to the CXC chemokine family. It is constitutively expressed in the lung and can be detected in trachea, stomach and skeletal muscle. CXCL17 attracts dendritic cells and monocytes and is regulated in tumors. It may be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues and may play a role in the innate defense against infections. Mature human CXCL17 shares 73%, 71% and 64% amino acid sequence identity with bovine, mouse and rat CXCL17, respectively.

Amino Acid Sequence

SSLNPGVARG HRDRGQASRR WLQEGGQECE CKDWFLRAPR RKFMTVSGLP KKQCPCDHFK GNVKKTRHQR HHRKPNKHSR ACQQFLKQCQ LRSFALPL

产品编号

产品名称

包装

KL6555-5μg

Recombinant Human VCC-1/CXCL17

5μg

KL6555-25μg

Recombinant Human VCC-1/CXCL17

25μg

KL6555-100μg

Recombinant Human VCC-1/CXCL17

100μg

KL6555-1mg

Recombinant Human VCC-1/CXCL17

1mg

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说明书

1份