Etoposide phosphate is a phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent.
Properties:
Density:1.55 g/cm3
Boiling Point:798.1ºC at 760 mmHg
Flash Point:263.6ºC
Storage Condition:-20ºC
Vapor Pressure:0mmHg at 25°C
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crene