| Product name： |
TNF-R2 Polyclonal Antibody |
| Alternative Names： |
TNFRSF1B; TNFBR; TNFR2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha rec |
| Applications： |
WB,IHC-p,IF,ELISA |
| Reactivity： |
Human,Mouse,Rat |
| Gene Name： |
TNFRSF1B |
| Protein Name： |
Tumor necrosis factor receptor superfamily member 1B |
| Human Gene Id： |
7133 |
| Human Swiss Prot No： |
P20333 |
| Mouse Gene Id： |
21938 |
| Mouse Swiss Prot No： |
P25119 |
| Rat Gene Id： |
156767 |
| Rat Swiss Prot No： |
Q80WY6 |
| Immunogen： |
The antiserum was produced against synthesized peptide derived from human TNF Receptor II. AA range:376-425 |
| Specificity： |
TNF-R2 Polyclonal Antibody detects endogenous levels of TNF-R2 protein. |
| Formulation： |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source： |
Rabbit |
| Dilution： |
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification： |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration： |
1 mg/ml |
| Storage Stability： |
-20°C/1 year |
| MolecularWeight(Da)： |
48291 |
| Observed Band(KD)： |
48 |
| Background： |
TNF receptor superfamily member 1B(TNFRSF1B) Homo sapiens The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008], |
| Function： |
function:Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.,online information:Clinical information on Enbrel,pharmaceutical:Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors.,PTM:A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by |
| Subcellular Location： |
extracellular region,nucleus,plasma membrane,integral component of plasma membrane,integral component of membrane,neuronal cell body,varicosity,membrane raft,perinuclear region of cytoplasm, |
| Expression： |
Muscle,PNS,Urine, |
关键字： ANTI-TNF RECEPTOR II;抗体;ANTI-TNF-R2;
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