ANTI-TNF RECEPTOR II抗体

ANTI-TNF RECEPTOR II抗体
  • ANTI-TNF RECEPTOR II抗体
  • 价格 询价
  • 包装50ul
  • CAS号
  • 中文名称ANTI-TNF RECEPTOR II抗体
  • 英文名称
  • 发布时间2020/10/26 8:27:23

产品属性

  • 产品名称: ANTI-TNF RECEPTOR II抗体
  • 包装价格: 50ul/RMB
  • 产品类别: 抗体
2020/10/26 8:27:23 ANTI-TNF RECEPTOR II抗体 50ul/RMB 抗体

产品描述

Product name: TNF-R2 Polyclonal Antibody
Alternative Names: TNFRSF1B; TNFBR; TNFR2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha rec
Applications: WB,IHC-p,IF,ELISA
Reactivity: Human,Mouse,Rat
Gene Name: TNFRSF1B
Protein Name: Tumor necrosis factor receptor superfamily member 1B
Human Gene Id: 7133
Human Swiss Prot No: P20333
Mouse Gene Id: 21938
Mouse Swiss Prot No: P25119
Rat Gene Id: 156767
Rat Swiss Prot No: Q80WY6
Immunogen: The antiserum was produced against synthesized peptide derived from human TNF Receptor II. AA range:376-425
Specificity: TNF-R2 Polyclonal Antibody detects endogenous levels of TNF-R2 protein.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: Rabbit
Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
Storage Stability: -20°C/1 year
MolecularWeight(Da): 48291
Observed Band(KD): 48
Background: TNF receptor superfamily member 1B(TNFRSF1B) Homo sapiens The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008],
Function: function:Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.,online information:Clinical information on Enbrel,pharmaceutical:Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors.,PTM:A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by
Subcellular Location: extracellular region,nucleus,plasma membrane,integral component of plasma membrane,integral component of membrane,neuronal cell body,varicosity,membrane raft,perinuclear region of cytoplasm,
Expression: Muscle,PNS,Urine,
 
 
关键字: ANTI-TNF RECEPTOR II;抗体;ANTI-TNF-R2;

公司简介

ELK Biotechnology位于武汉市东湖新技术开发区,是一家专业从事生命科学、免疫研究的高新技术生物企业。 我们拥有1000平方米的实验室,拥有独立的细胞培养室和SPF动物室,专业从事形态学病理学、细胞生物学、分子生物学、蛋白质免疫学、模型动物相关产品的引进和研发。公司自成立以来,团队成员先后参与多项医学生物学研究项目和国家自然科学基金项目。并与全国多家企业和科研机构建立合作关系,为每一位科研人员提供最优质、最高效的实验服务。 我们是具有研发、生产能力的试剂厂商。 ELK Biotechnology专业生产ELISA试剂盒、抗体及分子生物学试剂(DNA、RNA提取试剂盒及PCR相关试剂)。 拥有约7000 + ELISA试剂盒、11000 +抗体、50+种分子生物学试剂及细胞实验相关产品。 ELK Biotechnology是可靠的供应商,以优良的质量和有竞争力的价格。 我们正在扩展我们的产品线以满足客户的需求。 每一件产品都经过QC平台的严格检验,高品质得到强有力的保证。 我们的目标是为科学家提供最尖端、最具成本效益的研究工具。 我们的使命是为全世界的研究人员提供最好的解决方案和最可靠的合作伙伴。

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