ChemicalBook
Chemical Safety Data Sheet MSDS / SDS

4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE

Revision Date:2026-03-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE
  • CBnumber: CB9105234
  • CAS: 3223-07-2
  • EINECS Number: 643-091-8
  • Synonyms: MELPHALAN HCL

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P501 Dispose of contents/container to..…
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P320 Specific treatment is urgent (see … on this label).
P310 Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P284 Wear respiratory protection.
P271 Use only outdoors or in a well-ventilated area.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P501 Dispose of contents/container to..…
P405 Store locked up.
P330 Rinse mouth.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P501 Dispose of contents/container to..…
P405 Store locked up.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P281 Use personal protective equipment as required.
P202 Do not handle until all safety precautions have been read and understood.
P201 Obtain special instructions before use.
P501 Dispose of contents/container to..…
P405 Store locked up.
P363 Wash contaminated clothing before reuse.
P361 Remove/Take off immediately all contaminated clothing.
P322 Specific measures (see …on this label).
P310 Immediately call a POISON CENTER or doctor/physician.
P302+P350 IF ON SKIN: Gently wash with plenty of soap and water.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P262 Do not get in eyes, on skin, or on clothing.
Hazard statements
H300 Fatal if swallowed
H310 Fatal in contact with skin
H350 May cause cancer
H340 May cause genetic defects
H361 Suspected of damaging fertility or the unborn child
H330 Fatal if inhaled

SECTION 3: Composition/information on ingredients

Substance

  • Product name: 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE
  • Synonyms: MELPHALAN HCL
  • CAS: 3223-07-2
  • EC number: 643-091-8
  • MF: C13H19Cl3N2O2
  • MW: 341.66

SECTION 4: First aid measures

First Aid Measures

General advice
Consult a physician if necessary. Remove to fresh air.
Eye contact
Wash with plenty of water.
Skin Contact
Wash skin with soap and water.
Inhalation
Remove to fresh air If breathing is difficult, give oxygen If not breathing, give artificial respiration
Ingestion
Never give anything by mouth to an unconscious person. Clean mouth with water.

Most important symptoms and effects, both acute and delayed

Symptoms
No information available.

Indication of any immediate medical attention and special treatment needed

Note to physicians
Treat symptomatically.

SECTION 5: Firefighting measures

Suitable Extinguishing Media

Suitable Extinguishing Media
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable Extinguishing Media
None.

Specific hazards arising from the chemical

Specific hazards arising from the chemical
Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
Hazardous combustion products
Carbon oxides. Nitrogen oxides (NOx). Phosgene.

Explosion data

Sensitivity to Mechanical Impact
No information available.
Sensitivity to Static Discharge
No information available.

Protective equipment and precautions for firefighters

Protective equipment and precautions for firefighters
As in any fire, wear self contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Personal precautions
Ensure adequate ventilation, especially in confined areas.

Environmental precautions

Environmental precautions
See Section 12 for additional Ecological Information.

Methods and material for containment and cleaning up

Methods for containment
Prevent further leakage or spillage if safe to do so.
Methods for cleaning up
Use personal protective equipment as required. Cover powder spill with plastic sheet or tarp to minimize spreading and keep powder dry. Take up mechanically, placing in appropriate containers for disposal. Avoid creating dust. Clean contaminated surface thoroughly.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling
Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard.
Wear protective gloves/clothing and eye/face protection. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.

Conditions for safe storage, including any incompatibilities

Storage Conditions
Keep containers tightly closed in a dry, cool and well-ventilated place. Store at room temperature.
Incompatible materials
None known based on information supplied.

SECTION 8: Exposure controls/personal protection

Control parameters

Exposure Guidelines
This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies.

Appropriate engineering controls

Engineering Controls
Showers
Eyewash stations
Ventilation systems

Individual protection measures, such as personal protective equipment

Eye/face protection
Wear safety glasses with side shields (or goggles).
Skin and Body Protection
Wear protective gloves and protective clothing.
Respiratory protection
If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required for high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations.
General Hygiene Considerations
Handle in accordance with good industrial hygiene and safety practice.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical StateSolid
  • AppearanceNo information available
  • OdorNo information available
  • pHNo information available
  • Melting point/freezing pointNo information available
  • Boiling pointNo information available
  • Flash pointNo information available
  • DensityNo information available
  • Evaporation rateNo information available
  • Upper flammability limitsNo information available
  • Lower flammability limitNo information available
  • Vapor pressureNo information available
  • Vapor densityNo information available
  • Specific gravityNo information available
  • Water solubilityNo information available
  • Solubility in other solventsNo information available
  • Partition coefficient-0.52
  • Autoignition temperatureNo information available
  • Decomposition temperatureNo information available
  • Kinematic viscosityNo information available
  • Explosive propertiesNo information available
  • Oxidizing propertiesNo information available
  • SolubilityAqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
  • ColourWhite to Off-White

SECTION 10: Stability and reactivity

Reactivity

Not applicable

Chemical stability

Stable under recommended storage conditions.

Possibility of Hazardous Reactions

None under normal processing.

Hazardous polymerization

No information available.

Conditions to avoid

Extremes of temperature and direct sunlight.

Incompatible materials

Strong oxidizing agents.

Hazardous Decomposition Products

Carbon oxides. Nitrogen oxides (NOx). Phosgene.

SECTION 11: Toxicological information

Information on likely routes of exposure

Inhalation
Classified based on available data. For more details, see section 2.
Eye contact
Classified based on available data. For more details, see section 2.
Skin Contact
Classified based on available data. For more details, see section 2.
Ingestion
Classified based on available data. For more details, see section 2.

Information on toxicological effects

Symptoms
Classified based on available data. For more details, see section 2.

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Chronic Toxicity
Classified based on available data. For more details, see section 2. Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Chemical Name ACGIH IARC NTP OSHA

Melphalan hydrochloride - Group
1 - X 3223-07-2

Numerical measures of toxicity - Product Information

Unknown acute toxicity
Classified based on available data. For more details, see section 2
The following values are calculated based on chapter 3.1 of the GHS document
ATEmix (oral)
0 mg/kg

SECTION 12: Ecological information

Ecotoxicity

May cause long lasting harmful effects to aquatic life
100% of the mixture consists of components(s) of unknown hazards to the aquatic environment.

Persistence and degradability

No information available.

Bioaccumulation

No information available.

Mobility

No information available.

SECTION 13: Disposal considerations

Disposal of wastes

Disposal should be in accordance with applicable regional, national and local laws and regulations.

Contaminated packaging

Do not reuse container.

SECTION 14: Transport information

DOT

UN/ID no
UN2811
Hazard Class
6.1
Packing Group
I
Proper shipping name
Toxic solids, organic, n.o.s.
Description
UN2811, Toxic solids, organic, n.o.s., 6.1, I, POISON
Emergency Response Guide Number
154

IMDG

UN/ID no
UN2811
Hazard Class
6.1
Packing Group
I
Proper shipping name
Toxic solid, organic, n.o.s.
Description
UN2811, Toxic solid, organic, n.o.s., 6.1, I
Special Provisions
274
EmS-No
F-A, S-A

IATA

UN/ID no
UN2811
Hazard Class
6.1
Packing Group
I
Proper shipping name
Toxic solid, organic, n.o.s.
Description
UN2811, Toxic solid, organic, n.o.s., 6.1, I

SECTION 15: Regulatory information

International Inventories

All of the components in the product are on the following Inventory lists
X - Listed
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances

US Federal Regulations

SARA 313

Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.

SARA 311/312 Hazard Categories

Acute health hazard
No
Chronic Health Hazard
No
Fire hazard
No
Sudden release of pressure hazard
No
Reactive hazard
No

CWA (Clean Water Act)

This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40
CFR 122.42).

US State Regulations

California Proposition 65

This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know Regulations

This product does not contain any substances regulated by state right-to-know regulations

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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