4-Nitrotoluene

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

H225 Highly Flammable liquid and vapour

H301 Toxic if swalloed

H311 Toxic in contact with skin

H319 Causes serious eye irritation

H331 Toxic if inhaled

H373 May cause damage to organs through prolonged or repeated exposure

H401 Toxic to aquatic life

H411 Toxic to aquatic life with long lasting effects

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P309 IF exposed or if you feel unwell:

P310 Immediately call a POISON CENTER or doctor/physician.

P311 Call a POISON CENTER or doctor/physician.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352 IF ON SKIN: wash with plenty of soap and water.

P337+P313 IF eye irritation persists: Get medical advice/attention.

P403+P235 Store in a well-ventilated place. Keep cool.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

P391 Collect spillage.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Rinse and then wash skin with water and soap. Refer for medical attention . Wear protective gloves when administering first aid.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

INHALATION, INGESTION, OR SKIN: Headache, flushed face, dizziness, dyspnea (difficult breathing), cyanosis, nausea, vomiting, muscular weakness, rapid pulse and respiration, irritability, and convulsions. (USCG, 1999)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Aromatic hydrocarbons and related compounds

Use dry chemical, carbon dioxide, or water spray. Water streams or foam may cause frothing. Use water spray to keep fire-exposed containers cool. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Extinguish fire using agent suitable for surrounding fire.

Special Hazards of Combustion Products: Yields toxic oxides of nitrogen when burning. (USCG, 1999)

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Ventilate area of spill or leak. For small quantities of liq nitrotoluene, absorb on paper towels. For small quantities of solid nitrotoluene, sweep onto paper or other suitable material. Remove to safe place (such as fume hood) & burn. Large quantities of liq nitrotoluene can be collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device. Large quantities of solid nitrotoluene can be reclaimed; ... If not practical, dissolve in flammable solvent (such as alcohol) & atomize in suitable combustion chamber equipped with appropriate effluent gas cleaning device. Nitrotoluene

NO open flames. NO contact with oxidizing agents. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from food and feedstuffs. See Chemical Dangers. Well closed.Store in a cool. dry, well-ventilated location. Separate from acids, alkalies, oxidizing materials, and reducing agents.

TLV: 2 ppm as TWA; (skin); BEI issued.MAK: skin absorption (H); carcinogen category: 3B

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles, face shield or eye protection in combination with breathing protection.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

Decomposes on heating. This produces toxic fumes of nitrogen oxides. Reacts violently with strong oxidants and sulfuric acid. This generates fire and explosion hazard. Attacks some forms of plastic, rubber and coatings.

Heat contributes/ ... to instability. Nitrotoluene

Combustible when exposed to heat or flame.P-NITROTOLUENE may react violently with sodium, tetranitromethane, strong oxidizing agents , sulfuric acid and other acids. (NTP, 1992)

no data available

Decomposes on contact with strong oxidzers; strong acids; reducing agents; strong bases; ammonia, amines producing toxic fumes, causing fire and explosion hazard. Heat above 190 deg C may cause explosive decomposition. Attacks some plastics, rubbers, and coatings.

The substance decomposes on heating producing toxic fumes /of/ (nitrogen oxides).

no data available

no data available

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Evaluation: There is inadequate evidence in humans for the carcinogenicity of nitrotoluenes. There is inadequate evidence in experimental animals for the carcinogenicity of ... 4-nitrotoluene. ... Overall evaluation: Nitrotoluenes are not classifiable as to their carcinogenicity to humans (Group 3).

no data available

The substance is irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.

The substance may have effects on the blood, liver and testes.

Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

AEROBIC: 4-Nitrotoluene, present at 100 mg/L, reached 0.8% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1) which indicates the compound is not readily biodegradable(1). Two studies demonstrated that 4-nitrotoluene could be completely degraded by unacclimated sludge withing two weeks when lower concentrations of 4-nitrotoluene (10 ppm) were used(2,3). When nitrotoluene-adapted activated sludges were used as an inoculum, however, 4-nitrotoluene was almost completely degraded (~98%) within 5 days, even when higher concentrations (200 mg/L) of 4-nitrotoluene were used(4). 2-Amino-4-methylphenol has been identified as a microbial degradation product of 4-nitrotoluene(5). Using a mixed culture isolated from a contaminated soil (near an ammunition plant), 4-nitrotoluene (at initial concentrations of 5 mg/L) degraded completely in 1 to 3 days in aerobic batch and continuous reactor tests(6).

An estimated BCF of 13 was calculated for 4-nitrotoluene(SRC), using a log Kow of 2.37(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). The BCF for 4-nitrotoluene has been measured to be low in an unidentified fish and in carp (Carprinus carpio)(4,5).

A log Koc value of 2.14 (Koc = 138) was experimentally determined for 4-nitrotoluene in a single lake sediment from China(1). Using a structure estimation method based on molecular connectivity indices(2), the Koc of 4-nitrotoluene can be estimated to be 363(SRC). According to a classification scheme(3), the estimated and experimental Koc values suggest that 4-nitrotoluene is expected to have high to moderate mobility in soil.

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN3446 (For reference only, please check.)

IMDG: UN3446 (For reference only, please check.)

IATA: UN3446 (For reference only, please check.)

ADR/RID: NITROTOLUENES, SOLID (For reference only, please check.)

IMDG: NITROTOLUENES, SOLID (For reference only, please check.)

IATA: NITROTOLUENES, SOLID (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Depending on the degree of exposure, periodic medical examination is suggested.