Chemical Safety Data Sheet MSDS / SDS
CROTONALDEHYDE
Revision Date:2026-05-16Revision Number:1
Product identifier
- Product name: CROTONALDEHYDE
- CBnumber: CB6733702
- CAS: 4170-30-3
- EINECS Number: 224-030-0
- Synonyms: 2-Butenal,butenal
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P201 Obtain special instructions before use.
Hazard statements
H400 Very toxic to aquatic life
H373 May cause damage to organs through prolonged or repeated exposure
H341 Suspected of causing genetic defects
H335 May cause respiratory irritation
H330 Fatal if inhaled
H318 Causes serious eye damage
H315 Causes skin irritation
H225 Highly Flammable liquid and vapour
Substance
- Product name: CROTONALDEHYDE
- Synonyms: 2-Butenal,butenal
- CAS: 4170-30-3
- EC number: 224-030-0
- MF: C4H6O
- MW: 70.09
Eye Contact
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required.
Skin Contact
Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.
Inhalation
Remove to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Immediate medical attention is required.
Ingestion
Do NOT induce vomiting. Call a physician or poison control center immediately.
Most important symptoms and effects
Difficulty in breathing. Causes eye burns. . Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting
Self-Protection of the First Aider
Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination.
Notes to Physician
Treat symptomatically.
Suitable Extinguishing Media
Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may be used to cool closed containers.
Extinguishing media which must not be used for safety reasons
No information available.
Specific Hazards Arising from the Chemical
Flammable. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Do not allow run-off from fire-fighting to enter drains or water courses.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.
NFPA 704
4
3
2
| HEALTH | 4 | Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 2 | Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium) | |
| SPEC. HAZ. |
Personal Precautions
Use personal protective equipment as required. Keep people away from and upwind of spill/leak. Evacuate personnel to safe areas. Remove all sources of ignition. Take precautionary measures against static discharges.
Environmental Precautions
Do not flush into surface water or sanitary sewer system. Do not allow material to contaminate ground water system. Prevent product from entering drains. Local authorities should be advised if significant spillages cannot be contained. See Section 12 for additional Ecological Information. Avoid release to the environment. Collect spillage.
Methods for Containment and Clean Up
Soak up with inert absorbent material. Keep in suitable, closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.
Refer to protective measures listed in Sections 8 and 13.
Refer to protective measures listed in Sections 8 and 13.
Handling
Use only under a chemical fume hood. Wear personal protective equipment/face protection. Do not get in eyes, on skin, or on clothing. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. Use spark-proof tools and explosion-proof equipment. Do not breathe (dust, vapor, mist, gas). Do not ingest. If swallowed then seek immediate medical assistance. Take precautionary measures against static discharges. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded.
Storage
Keep containers tightly closed in a dry, cool and well-ventilated place. Flammables area. Keep away from heat, sparks and flame.
Store under an inert atmosphere. Reacts with air to form peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals.
Store under an inert atmosphere. Reacts with air to form peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals.
Specific Use(s)
Use in laboratories
Control Parameters
| Component | China | Taiwan | Thailand | Hong Kong |
|---|---|---|---|---|
| Crotonaldehyde | Ceiling: 12 mg/m3 | TWA: 2 ppm TWA: 5.7 mg/m3 | - |
| Component | ACGIH TLV | OSHA PEL | NIOSH | The United Kingdom | European Union |
|---|---|---|---|---|---|
| Crotonaldehyde | Ceiling: 0.3 ppm Skin | (Vacated) TWA: 2 ppm (Vacated) TWA: 6 mg/m3 TWA: 2 ppm TWA: 6 mg/m3 | IDLH: 50 ppm REL = 2 ppm (TWA) REL = 6 mg/m3 (TWA) | - |
Legend
ACGIH
- American Conference of Governmental Industrial Hygienists
OSHA
- Occupational Safety and Health Administration
NIOSH
NIOSH - National Institute for Occupational Safety and Health
Monitoring methods
BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents. MDHS70 General methods for sampling airborne gases and vapours MDHS 88
Volatile organic compounds in air. Laboratory method using diffusive samplers, solvent desorption and gas chromatography MDHS 96 Volatile organic compounds in air - Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography
Volatile organic compounds in air. Laboratory method using diffusive samplers, solvent desorption and gas chromatography MDHS 96 Volatile organic compounds in air - Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography
Exposure Controls
Engineering Measures
Use only under a chemical fume hood. Ensure that eyewash stations and safety showers are close to the workstation location. Use explosion-proof electrical/ventilating/lighting equipment. Ensure adequate ventilation, especially in confined areas. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source.
Personal protective equipment
Eye ProtectionGoggles (European standard - EN 166)
Hand Protection
Protective gloves
Neoprene
Natural rubber
PVC
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Skin and body protection
Neoprene
Natural rubber
PVC
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
| Glove material | Breakthrough time | Glove thickness | EU standard | Glove comments |
|---|---|---|---|---|
| Butyl rubber | < 120 minutes | 0.7 mm | Level 41 | As tested under EN374-3 Determination of |
| Nitrile rubber | EN 374 | Resistance to Permeation by Chemicals |
Wear appropriate protective gloves and clothing to prevent skin exposure
Respiratory Protection
When workers are facing concentrations above the exposure limit they must use appropriate certified respirators.
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
Large scale/emergency use
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced
Recommended Filter type: Organic gases and vapours filter Type A Brown conforming to
EN14387
Small scale/Laboratory use
Recommended Filter type: Organic gases and vapours filter Type A Brown conforming to
EN14387
Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN 141
When RPE is used a face piece Fit Test should be conducted
Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN 141
When RPE is used a face piece Fit Test should be conducted
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice.
Environmental exposure controls
Prevent product from entering drains. Do not allow material to contaminate ground water system. Local authorities should be advised if significant spillages cannot be contained.
Information on basic physicochemical properties
- Molecular Weight70.09
- Molecular FormulaC4 H6 O
- Oxidizing PropertiesNot applicable
- Explosive PropertiesNot applicable
- Viscosity0.27 mPa*s @ 20°C Calculated
- Decomposition TemperatureNo data available
- Autoignition Temperature155 °C / 311 °
F DIN 51794 - Partition Coefficient (n-octanol/water)No data available
- Solubility in other solventsMiscible with alcohol, benzene, gasoline, kerosene, solvent naphtha, and toluene (Hawley, 1981)
- Water Solubility150 g/l (20°C)
- Bulk DensityNot applicable Liquid
- ColourColourless
- Henry's Law Constant1.92 x 10-5 atmm3/mol (Buttery et al., 1971)
- Specific Gravity / Density0.858
- Vapor Density2.4 1 (Air = 1.0)
- Vapor Pressure40 mbar @ 20 °C
- Explosion LimitsLower 2.1 vol%
Upper 15.5 vol% - Flammability (solid,gas)Not applicable Liquid
- Evaporation RateNo data available
- Flash Point13 °C / 55.4 °F Method - CC (closed cup)
- Boiling Point/Range101 - 103 °C / 213.8 - 217.4 °F @ 760 mmHg
- Softening PointNo data available
- Melting Point/Range74 °C / -101.2 °F
- pHNo information available
- Odor Threshold0.0210 mg/l
- Odorpungent
- Physical StateLiquid
- AppearanceClear
Stability
Air sensitive.
Hazardous Reactions
May form explosive peroxides.
Hazardous Polymerization
Hazardous polymerization may occur.
Conditions to Avoid
Incompatible products. Excess heat. Keep away from open flames, hot surfaces and sources of ignition. Exposure to air.
Materials to avoid
Strong oxidizing agents. Strong reducing agents. Bases. Ammonia.
Hazardous Decomposition Products
Carbon monoxide (CO). Carbon dioxide (CO2).
Product Information
(a) acute toxicity;
| Component | LD50 Oral | LD50 Dermal | LC50 Inhalation |
|---|---|---|---|
| Crotonaldehyde | 174 mg/kg (rat) OECD 420 | 26 mg/kg (Guinea pig) | 336 mg/m3 ( Rat ) 4h (OECD 403) |
(b) skin corrosion/irritation;
Category 2
(c) serious eye damage/irritation;
Category 1
(d) respiratory or skin sensitization;
RespiratoryBased on available data, the classification criteria are not met
Skin
Based on available data, the classification criteria are not met
(e) germ cell mutagenicity;
Category 2
(f) carcinogenicity;
Based on available data, the classification criteria are not met
The table below indicates whether each agency has listed any ingredient as a carcinogen
The table below indicates whether each agency has listed any ingredient as a carcinogen
| Component | EU | UK | Germany | IARC |
|---|---|---|---|---|
| Crotonaldehyde | Group 2B |
(g) reproductive toxicity;
Based on available data, the classification criteria are not met
(h) STOT-single exposure;
Category 3
Results / Target organs
Respiratory system
(i) STOT-repeated exposure;
Category 2
Target Organs
Nasal Cavities.
(j) aspiration hazard;
Based on available data, the classification criteria are not met
Symptoms / effects,both acute and delayed
Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting
Ecotoxicity effects
The product contains following substances which are hazardous for the environment. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
| Component | Freshwater Fish | Water Flea | Freshwater Algae | Microtox |
|---|---|---|---|---|
| Crotonaldehyde | LC50: = 0.84 mg/L, 96h flow-through (Pimephales promelas) LC50: = 3.5 mg/L, 96h static (Lepomis macrochirus) LC50: = 0.65 mg/L, 96h flow-through (Oncorhynchus mykiss) | EC50: = 2 mg/L, 48h (Daphnia magna) | EC50 = 20 mg/L 48 h |
Persistence and Degradability
Readily biodegradable
Persistence
Soluble in water, Persistence is unlikely, based on information available.
Degradation in sewage
Contains substances known to be hazardous to the environment or not degradable in waste
treatment plant
water treatment plants.
Bioaccumulative Potential
Bioaccumulation is unlikely; Bioaccumulation is unlikely
Mobility in soil
The product is water soluble, and may spread in water systems Will likely be mobile in the environment due to its water solubility Highly mobile in soils
Endocrine Disruptor Information
This product does not contain any known or suspected endocrine disruptors
Persistent Organic Pollutant
This product does not contain any known or suspected substance
Ozone Depletion Potential
This product does not contain any known or suspected substance
Waste from Residues/Unused Products
Waste is classified as hazardous. Dispose of in accordance with the European Directives on waste and hazardous waste. Dispose of in accordance with local regulations.
Contaminated Packaging
Dispose of this container to hazardous or special waste collection point. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep product and empty container away from heat and sources of ignition.
Other Information
Do not flush to sewer. Waste codes should be assigned by the user based on the application for which the product was used. Can be landfilled or incinerated, when in compliance with local regulations. Do not empty into drains. Do not let this chemical enter the environment.
Road and Rail Transport
UN-NoUN1143
Proper Shipping Name
CROTONALDEHYDE
Hazard Class
6.1
Subsidiary Hazard Class
3
Packing Group
I
IMDG/IMO
UN-NoUN1143
Proper Shipping Name
CROTONALDEHYDE
Hazard Class
6.1
Subsidiary Hazard Class
3
Packing Group
I
IATA
FORBIDDEN FOR IATA TRANSPORT
UN-No
UN1143
Proper Shipping Name
CROTONALDEHYDE FORBIDDEN FOR IATA TRANSPORT
Hazard Class
6.1
Subsidiary Hazard Class
3
Packing Group
I
Special Precautions for User
No special precautions required
International Inventories
X = listed, China (IECSC), Europe (EINECS/ELINCS/NLP), U.S.A. (TSCA), Canada (DSL/NDSL), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), Korea (KECL).
| Component | The Inventory of Hazardous Chemicals (2015 Edition) | List of dangerous goods GB 12268 - 2012 | TCSI | IECSC | EINECS | TSCA | DSL | PICCS | ENCS | ISHL | AICS | KECL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Crotonaldehyde | X | X | X | X | 224-030-0 | X | X | X | X | X | X | KE-05-0370 |
National Regulations
| Component | Toxic Chemical Substances Control Act |
|---|---|
| Crotonaldehyde 4170-30-3 ( > 95 ) | Class IV (1 wt%) |
Prepared By
Health, Safety and Environmental Department
Creation Date
02-Jun-2009
Revision Date
07-Sep-2025
Revision Summary
Not applicable.
Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene.
First aid for chemical exposure, including the use of eye wash and safety showers.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards.
Fire prevention and fighting, identifying hazards and risks, static electricity, explosive atmospheres posed by vapours and dusts.
Chemical incident response training.
First aid for chemical exposure, including the use of eye wash and safety showers.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards.
Fire prevention and fighting, identifying hazards and risks, static electricity, explosive atmospheres posed by vapours and dusts.
Chemical incident response training.
Legend
CASChemical Abstracts Service
TSCA
United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS
Inventory
European Inventory of Existing Commercial Chemical
Substances/EU List of Notified Chemical Substances
DSL/NDSL
Substances/EU List of Notified Chemical Substances
Canadian Domestic Substances List/Non-Domestic
Substances List
PICCS
Substances List
Philippines Inventory of Chemicals and Chemical Substances
ENCS
Japanese Existing and New Chemical Substances
IECSC
Chinese Inventory of Existing Chemical Substances
AICS
Australian Inventory of Chemical Substances
KECL
Korean Existing and Evaluated Chemical Substances
NZIoC
New Zealand Inventory of Chemicals
WEL
Workplace Exposure Limit
TWA
Time Weighted Average
ACGIH
American Conference of Governmental Industrial Hygienists
IARC
International Agency for Research on Cancer
DNEL
Derived No Effect Level
PNEC
Predicted No Effect Concentration
RPE
Respiratory Protective Equipment
LD50
Lethal Dose 50%
LC50
Lethal Concentration 50%
EC50
Effective Concentration 50%
NOEC
No Observed Effect Concentration
POW
Partition coefficient Octanol:Water
PBT
Persistent, Bioaccumulative, Toxic
vPvB
very Persistent, very Bioaccumulative
ICAO/IATA
International Civil Aviation Organization/International Air
Transport Association
IMO/IMDG
Transport Association
International Maritime Organization/International Maritime
Dangerous Goods Code
ADR
Dangerous Goods Code
European Agreement Concerning the International Carriage of
Dangerous Goods by Road
MARPOL
Dangerous Goods by Road
International Convention for the Prevention of Pollution from
Ships
OECD
Ships
Organisation for Economic Co-operation and Development
ATE
Acute Toxicity Estimate
BCF
Bioconcentration factor
VOC
(Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.