11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male and female - > 2,000 - 5,000 mg/kg (OECD Test Guideline 401)
Remarks: LC50 Inhalation - Rat - male and female - 6 h - 17 mg/l - aerosol
Remarks: (ECHA)
Inhalation: Irritating to respiratory system.
LD50 Dermal - Rabbit - 6,400 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: 4,4'- isopropylidenediphenol
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes serious eye damage.
(OECD Test Guideline 405)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Respiratory or skin sensitization
Human experience
Result: positive
Remarks: (External MSDS)
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Germ cell mutagenicity
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenolTest
Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenolTest
Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Test Type: In vivo micronucleus test
Species: Mouse
Cell type: Bone marrow
Application Route: Oral
Result: negative
Remarks: (ECHA)
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
May damage fertility.
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation. - Respiratory system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Systemic effects:
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Headache
Dizziness
Drowsiness agitation
CNS disorders
Unconsciousness respiratory arrest
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Damage to:
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Kidney
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Other dangerous properties can not be excluded.
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol
Handle in accordance with good industrial hygiene and safety practice.
The value is given in analogy to the following substances: 4,4'-isopropylidenediphenol