Chemical Safety Data Sheet MSDS / SDS

Cephalothin sodium

Revision Date:2022-12-24Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Cephalothin sodium
  • CBnumber: CB9443527
  • CAS: 58-71-9
  • EINECS Number: 200-394-6
  • Synonyms: cephalothin sodium,CEFALOTIN SODIUM

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

Classification of the substance or mixture

Skin sensitization, Category 1

Respiratory sensitization, Category 1

Label elements

Pictogram(s)
  • Signal wordDanger
Hazard statement(s)

H317 May cause an allergic skin reaction

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statement(s)

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P284 Wear respiratory protection.

P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Prevention

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P284 [In case of inadequate ventilation] wear respiratory protection.

Response

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P317 If skin irritation or rash occurs: Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately.

Storage

none

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards

no data available

SECTION 3: Composition/information on ingredients

Substance

  • Product name: Cephalothin sodium
  • Synonyms: cephalothin sodium,CEFALOTIN SODIUM
  • CAS: 58-71-9
  • EC number: 200-394-6
  • MF: C16H16N2O6S2.Na
  • MW: 418.42

SECTION 4: First aid measures

Description of first aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Most important symptoms and effects, both acute and delayed

no data available

Indication of any immediate medical attention and special treatment needed

Peritoneal dialysis removes all of cephalothin from blood in about 48 hr. Drug is also removed from circulation by hemodialysis ...

SECTION 5: Firefighting measures

Extinguishing media

Use dry chemical, carbon dioxide or alcohol-resistant foam.

Specific Hazards Arising from the Chemical

no data available

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

SECTION 7: Handling and storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

Exposure controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures

Eye/face protection

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Skin protection

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical stateneat
  • ColourWhite to Off-White
  • Odour

    no data available

  • Melting point/freezing point

    240°C

  • Boiling point or initial boiling point and boiling range

    757.2°C at 760 mmHg

  • Flammability

    no data available

  • Lower and upper explosion limit/flammability limit

    no data available

  • Flash point

    411.8°C

  • Auto-ignition temperature

    no data available

  • Decomposition temperature

    no data available

  • pH

    no data available

  • Kinematic viscosity

    no data available

  • SolubilityH2O: 50 mg/mL, clear, faintly yellow
  • Partition coefficient n-octanol/water

    log Kow = -0.41 (pH 2.0)

  • Vapour pressure

    1.7X10-14 mm Hg at 25 deg C (est)

  • Density and/or relative density

    no data available

  • Relative vapour density

    no data available

  • Particle characteristics

    no data available

SECTION 10: Stability and reactivity

Reactivity

no data available

Chemical stability

Solutions of cephalothin may darken, especially if stored at room temperature. A slight discoloration does not affect potency. Solutions stored under refrigeration may precipitate, but the precipitate can be redissolved by warming to room temperature with constant agitation.

Possibility of hazardous reactions

no data available

Conditions to avoid

no data available

Incompatible materials

no data available

Hazardous decomposition products

When heated to decomposition it emits very toxic fumes of nitroxides and sulfoxides.

SECTION 11: Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral >10,000 mg/kg sodium salt
  • Inhalation: no data available
  • Dermal: no data available
  • Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    no data available

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    SECTION 12: Ecological information

    Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available
  • Persistence and degradability

    no data available

    Bioaccumulative potential

    An estimated BCF of 0.3 was calculated for cephalothin(SRC), using a log Kow of -0.41(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

    Mobility in soil

    The Koc of cephalothin is estimated as 14(SRC), using a log Kow of -0.41(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that cephalothin is expected to have very high mobility in soil. An estimated pKa value of 3.8 (carboxylic acid)(SRC), calculated using a method based on linear free energy relationships and perturbed molecular orbital theory(4), indicates that this compound will exist primarily as an anion in the environment, and anions generally do not adsorb to soils as strongly as their neutral counterparts(5).

    Other adverse effects

    no data available

    SECTION 13: Disposal considerations

    Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    SECTION 14: Transport information

    UN Number

    ADR/RID: Not dangerous goods. (For reference only, please check.)

    IMDG: Not dangerous goods. (For reference only, please check.)

    IATA: Not dangerous goods. (For reference only, please check.)

    UN Proper Shipping Name

    ADR/RID: Not dangerous goods. (For reference only, please check.)

    IMDG: Not dangerous goods. (For reference only, please check.)

    IATA: Not dangerous goods. (For reference only, please check.)

    Transport hazard class(es)

    ADR/RID: Not dangerous goods. (For reference only, please check.)

    IMDG: Not dangerous goods. (For reference only, please check.)

    IATA: Not dangerous goods. (For reference only, please check.)

    Packing group, if applicable

    ADR/RID: Not dangerous goods. (For reference only, please check.)

    IMDG: Not dangerous goods. (For reference only, please check.)

    IATA: Not dangerous goods. (For reference only, please check.)

    Environmental hazards

    ADR/RID: No

    IMDG: No

    IATA: No

    Special precautions for user

    no data available

    Transport in bulk according to IMO instruments

    no data available

    SECTION 15: Regulatory information

    Safety, health and environmental regulations specific for the product in question

    European Inventory of Existing Commercial Chemical Substances (EINECS)
    Listed.
    EC Inventory
    Listed.
    United States Toxic Substances Control Act (TSCA) Inventory
    Not Listed.
    China Catalog of Hazardous chemicals 2015
    Not Listed.
    New Zealand Inventory of Chemicals (NZIoC)
    Listed.
    PICCS
    Not Listed.
    Vietnam National Chemical Inventory
    Listed.
    IECSC
    Not Listed.
    Korea Existing Chemicals List (KECL)
    Not Listed.

    SECTION 16: Other information

    Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%
  • References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/
  • Disclaimer:

    The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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