Chemical Safety Data Sheet MSDS / SDS
Cholecalciferol
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: Cholecalciferol
- CBnumber: CB52699362
- CAS: 80666-48-4
- Synonyms: Calciol-[D3];D3-Vitamin D3
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P242 Use only non-sparking tools.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P240 Ground/bond container and receiving equipment.
P233 Keep container tightly closed.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H319 Causes serious eye irritation
H225 Highly Flammable liquid and vapour
Substance
- Product name: Cholecalciferol
- Synonyms: Calciol-[D3];D3-Vitamin D3
- CAS: 80666-48-4
- MF: C27H41D3O
- MW: 387.656
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
Combustible. Pay attention to flashback. Vapors are heavier than air and may spread along floors. Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.
Hazardous combustion products
Carbon oxides
Specific extinguishing methods
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
In the event of fire, wear self-contained breathing apparatus.
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains. Risk of explosion.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of properly. Clean up affected area.
Handling
Advice on protection against fire and explosionKeep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge.
Storage
Further information on storage conditionsKeep container tightly closed in a dry and wellventilated place. Keep away from heat and sources of ignition.
Storage class
3, Flammable liquids
Recommended storage temperature
-20 °C
control parameter
Hazard composition and occupational exposure limitsDoes not contain substances with occupational exposure limits.
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Safety glasses
Skin and body protection
Safety glasses
Flame retardant antistatic protective clothing.
Hand protection
Remarks
required
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
Information on basic physicochemical properties
- Physical stateSolid
- Particle characteristics Particle sizeNo data available
- Molecular weight387.57 g/mol
- Oxidizing propertiesnone
- Explosive propertiesNot classified as explosive.
- Flow timeNo data available
- Viscosity, kinematicNo data available
- Viscosity, dynamicNo data available
- Decomposition temperatureNo data available
- Autoignition temperatureNo data available
- Partition coefficient: n-octanol/waterNo data available
- Water solubilityNo data available
- DensityNo data available
- Relative densityNo data available
- Relative vapor densityNo data available
- Vapor pressureNo data available
- Lower explosion limit / Lower flammability limitNo data available
- Upper explosion limit / Upper flammability limitNo data available
- Burning rateNo data available
- Flammability (liquids)No data available
- Flammability (solid, gas)No data available
- Evaporation rateNo data available
- Flash point14 °C
Method: closed cup - Boiling point/boiling rangeNo data available
- Melting point/ rangeNo data available
- pHNo data available
- Odor ThresholdNo data available
- OdorNo data available
- ColorWhite to off-white
- Appearanceliquid
Reactivity
Vapors may form explosive mixture with air.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
No data available
Conditions to avoid
Warming.
Incompatible materials
No data available
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Mixture Acute toxicityOral: No data available
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Skin corrosion/irritation
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Components ethanol
Handle in accordance with good industrial hygiene and safety practice.
Acute toxicity
LD50 Oral - Rat - male and female - 10,470 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - 124.7 mg/l - vapor (OECD Test Guideline 403)
Dermal: No data available
LC50 Inhalation - Rat - male and female - 4 h - 124.7 mg/l - vapor (OECD Test Guideline 403)
Dermal: No data available
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 24 h (OECD Test Guideline 404)
Result: No skin irritation - 24 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes serious eye irritation.
(OECD Test Guideline 405)
Result: Causes serious eye irritation.
(OECD Test Guideline 405)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: Methanol
Result: negative (OECD Test Guideline 406)
Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: Methanol
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: mouse lymphoma cells
Result: negative
Method: OECD Test Guideline 478
Species: Mouse - male
Result: Positive results were obtained in some in vivo tests.
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: mouse lymphoma cells
Result: negative
Method: OECD Test Guideline 478
Species: Mouse - male
Result: Positive results were obtained in some in vivo tests.
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
Ecotoxicity
Components:
ethanol:
Toxicity to fishLC50 (Pimephales promelas (fathead minnow)): 15,300 mg/l End point: mortality Exposure time: 96 h Test Type: flow-through test Analytical monitoring: yes Method: US-EPA
Toxicity to daphnia and other aquatic invertebrates
LC50 (Ceriodaphnia dubia (water flea)): 5,012 mg/l End point: mortality Exposure time: 48 h Test Type: static test Remarks: (ECHA)
Toxicity to algae/aquatic plants
ErC50 (Chlorella vulgaris (Fresh water algae)): 275 mg/l Exposure time: 72 h Test Type: static test Method: OECD Test Guideline 201
Toxicity to fish (Chronic toxicity)
NOEC (Danio rerio (zebra fish)): 250 mg/l Exposure time: 120 h Test Type: semi-static test Remarks: (ECHA)
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
NOEC (Daphnia magna (Water flea)): 9.6 mg/l End point: reproduction rate Exposure time: 9 d Test Type: semi-static test Remarks: (ECHA)
Toxicity to microorganisms
IC50 (activated sludge): > 1,000 mg/l Exposure time: 3 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 209 The value is given in analogy to the following sub- stances: Methanol
Persistence and degradability
Components:
ethanol:
Biodegradabilityaerobic Inoculum: activated sludge, non-adapted Result: Readily biodegradable. Biodegradation: ca. 95 % Exposure time: 15 d Method: OECD Test Guideline 301E
Biochemical Oxygen Demand (BOD)
930 - 1,670 mg/g Incubation time: 5 d Remarks: (Lit.)
ThOD
2,100 mg/g Remarks: (Lit.)
Bioaccumulative potential
Components:
ethanol:
BioaccumulationRemarks: Due to the distribution coefficient noctanol/water, accumulation in organisms is not expected.
Partition coefficient: noctanol/water
log Pow: -0.35 (24 °C) pH: 7.4 Method: OECD Test Guideline 107 Remarks: Bioaccumulation is not expected.
Mobility in soil
No data available
Other adverse effects
Components:
ethanol:
Results of PBT and vPvB assessmentSubstance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a li- censed disposal company.
International Regulations
IATA-DGR
UN/ID No. : UN 1170
Proper shipping name : Ethanol solution
Class : 3
Packing group : II
Labels : Class 3 - Flammable liquids
Packing instruction (cargo aircraft) : 364
Packing instruction (passenger aircraft) : 353
Proper shipping name : Ethanol solution
Class : 3
Packing group : II
Labels : Class 3 - Flammable liquids
Packing instruction (cargo aircraft) : 364
Packing instruction (passenger aircraft) : 353
IMDG-Code
UN number : UN 1170
Proper shipping name : ETHANOL SOLUTION
Class : 3
Packing group : II
Labels : 3
EmS Code : F-E, S-D
Marine pollutant : no
Proper shipping name : ETHANOL SOLUTION
Class : 3
Packing group : II
Labels : 3
EmS Code : F-E, S-D
Marine pollutant : no
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National regulation GB 6944/12268
UN number : UN 1170
Proper shipping name : ETHANOL
Class : 3
Packing group : II
Labels : 3
National regulation GB 6944/12268
UN number : UN 1170
Proper shipping name : ETHANOL
Class : 3
Packing group : II
Labels : 3
Special precautions for user
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals
Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)
No. / Code Chemical name / Category Threshold quantity
W5.3 Flammable liquids 1,000 t
Hazardous Chemicals for Priority Management
Not applicable under SAWS
Catalogue of Specially Controlled Hazardous
Listed Chemicals
List of Explosive Precursors
Not listed
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for Import and Export
Not applicable
Regulation on the Administration of Precursor Chemicals
Catalogue and Classification of Precursor Chemicals
Not listed
Regulations on the Administration of Controlled Chemicals
List of Controlled Chemicals
Not listed
Regulations of Ozone Depleting Substances Management
List of Controlled Ozone Depleting Substances
Not listed
List of Controlled Ozone Depleting Substances Import and Export
Not listed
Environmental Protection Law
List of Priority Controlled Chemicals
Not listed
List of Key Controlled New Pollutants
Not listed
Full text of other abbreviations
ACGIHUSA. ACGIH Threshold Limit Values (TLV)
ACGIH / STEL AIIC - Australian Invent Transport by Land of Bra bw - Body weight; CMR Standard of the German List (Canada); ECx - Conc associated with x% respo Chemical Substances (Jap response; ERG - Emerge GLP - Good Laboratory P cer; IATA - International Construction and Equipm Half maximal inhibitory c tion; IECSC - Inventory o tional Maritime Dangerou Industrial Safety and H Standardization; KECI - K tration to 50 % of a test (Median Lethal Dose); MA lution from Ships; n.o.s. No Observed (Adverse) E fect Level; NOELR - No Norm; NTP - National Toxi icals; OECD - Organizatio fice of Chemical Safety a and Toxic substance; PIC stances; (Q)SAR - (Quant (EC) No 1907/2006 of th Registration, Evaluation, Accelerating Decompositi Chemical Substance Inve Thailand Existing Chemica States); UN - United Nat Transport of Dangerous WHMIS - Workplace Hazar
Short-term exposure limit ry of Industrial Chemicals
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonized System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organization
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC fect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonized System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organization
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC fect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.