11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - female - > 2,000 mg/kg (N2-(Cyclopropyl-2,2,3,3-d4)-1,3,5-triazine- 2,4,6-triamine) (OECD Test Guideline 425)
Remarks: The value is given in analogy to the following substances: Cyromazine
LC50 Inhalation - Rat - 4 h - > 2,720 mg/m3 - dust/mist (N2-(Cyclopropyl-2,2,3,3-d4)-1,3,5-triazine-2,4,6-triamine)
Remarks: (RTECS)
The value is given in analogy to the following substances: Cyromazine
LD50 Dermal - Rat - > 3,100 mg/kg (N2-(Cyclopropyl-2,2,3,3-d4)-1,3,5-triazine-2,4,6- triamine)
Remarks: (RTECS)
The value is given in analogy to the following substances: Cyromazine
Skin corrosion/irritation
Skin - Rabbit (N2-(Cyclopropyl-2,2,3,3-d4)-1,3,5-triazine-2,4,6-triamine)
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: Cyromazine
Serious eye damage/eye irritation
Eyes - Rabbit (N2-(Cyclopropyl-2,2,3,3-d4)-1,3,5-triazine-2,4,6-triamine)
Result: No eye irritation (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: Cyromazine
Respiratory or skin sensitization
Maximization Test - Guinea pig (N2-(Cyclopropyl-2,2,3,3-d4)-1,3,5-triazine-2,4,6-triamine)
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: Cyromazine
Germ cell mutagenicity
Test Type: Ames test (N2-(Cyclopropyl-2,2,3,3-d4)-1,3,5-triazine-2,4,6-triamine)
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances:
CyromazineCarcinogenicity
No data available
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rabbit - male and female - Dermal - 21 Days - NOAEL (No observed adverse effect level) - 2,000 mg/kg
Remarks: The value is given in analogy to the following substances: Cyromazine (N2-(Cyclopropyl-2,2,3,3-d4)-1,3,5-triazine-2,4,6-triamine)
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. (N2-(Cyclopropyl-2,2,3,3-d4)-1,3,5-triazine-2,4,6-triamine)