11.1 Information on toxicological effects
Mixture Acute toxicity
Oral: No data available
Acute toxicity estimate Oral - 777.78 mg/kg (Calculation method)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Acute toxicity estimate Inhalation - 4 h - 7.88 mg/l - vapor(Calculation method)
Symptoms: Possible symptoms:, mucosal irritations, Cough, Shortness of breath,
Possible damages:, damage of respiratory tract
Acute toxicity estimate Dermal - 4,940 mg/kg (Calculation method)
Skin corrosion/irritation
Remarks: Mixture causes skin irritation.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Possible carcinogen.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Mixture may cause respiratory irritation.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Aspiration hazard, Aspiration may cause pulmonary edema and pneumonitis.
11.2 Additional Information
Acts as a simple asphyxiant by displacing air., anesthetic effects, Breathing difficul- ties, Headache, Dizziness, Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:, Redness, Blurred vision, Pro- vokes tears., Effects due to ingestion may include:
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components 1,2-Dichloroethane
Acute toxicity
LD50 Oral - Rat - male - 770 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - 7.8 mg/l - vapor (OECD Test Guideline 403)
LD50 Dermal - Rabbit - male - 4,890 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: irritating (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: S. typhimurium
Result: positive
Remarks: (ECHA)
Test Type: Ames test
Test system: Escherichia coli
Result: positive
Test Type: In vitro mammalian cell gene mutation test
Test system: human lymphoblastoid cells
Result: positive
Test Type: In vitro mammalian cell gene mutation test
Test system: human lymphoblastoid cells
Result: positive
Remarks: (ECHA)
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster lung cells
Result: positive
Remarks: (ECHA)
Test Type: unscheduled DNA synthesis assay
Test system: rat hepatocytes
Result: positive
Method: OECD Test Guideline 474
Species: Mouse - male and female
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female - Red blood cells (erythrocytes)
Result: negative
Species: Rat - female - mammary gland
Result: negative
Remarks: (ECHA)
Method: OECD Test Guideline 477
Species: Drosophila melanogaster - male - sperm
Result: positive
Species: Mouse - male
Result: negative
Remarks: (ECHA)
Carcinogenicity
Presumed to have carcinogenic potential for humans
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause respiratory irritation.
Specific target organ toxicity - repeated exposure Aspiration hazard
Aspiration may cause pulmonary edema and pneumonitis.