Chemical Safety Data Sheet MSDS / SDS
GRAYANOTOXIN III
Revision Date:2026-03-20Revision Number:1
Product identifier
- Product name: GRAYANOTOXIN III
- CBnumber: CB7674097
- CAS: 4678-45-9
- Synonyms: andromedol ;deacylasebotoxini
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P501 Dispose of contents/container to..…
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P321 Specific treatment (see … on this label).
P311 Call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P271 Use only outdoors or in a well-ventilated area.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P362 Take off contaminated clothing and wash before reuse.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P321 Specific treatment (see … on this label).
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264 Wash skin thouroughly after handling.
P501 Dispose of contents/container to..…
P405 Store locked up.
P363 Wash contaminated clothing before reuse.
P361 Remove/Take off immediately all contaminated clothing.
P322 Specific measures (see …on this label).
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264 Wash skin thouroughly after handling.
P501 Dispose of contents/container to..…
P405 Store locked up.
P330 Rinse mouth.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
Hazard statements
H311 Toxic in contact with skin
H331 Toxic if inhaled
H319 Causes serious eye irritation
H315 Causes skin irritation
H301 Toxic if swalloed
Substance
- Product name: GRAYANOTOXIN III
- Synonyms: andromedol ;deacylasebotoxini
- CAS: 4678-45-9
- MF: C20H34O6
- MW: 370.48
Description of first aid measures
General information
Immediately remove any clothing soiled by the product.
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
After inhalation
Supply fresh air; consult doctor in case of complaints.
After skin contact
Immediately rinse with water.
After eye contact
Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
After swallowing
Immediately call a doctor.
Most important symptoms and effects, both acute and delayed
No further relevant information available.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.
Extinguishing media
Suitable extinguishing agents
CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
Special hazards arising from the substance or mixture
No further relevant information available.
Advice for firefighters
Protective equipment
No special measures required.
Personal precautions, protective equipment and emergency procedures
Wear protective equipment. Keep unprotected persons away.
Environmental precautions
Dilute with plenty of water.
Do not allow to enter sewers/ surface or ground water.
Do not allow to enter sewers/ surface or ground water.
Methods and material for containment and cleaning up
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.
Protective Action Criteria for Chemicals
PAC-1
75-05-8 Acetonitrile 13 ppm
PAC-2
75-05-8 Acetonitrile 50 ppm
PAC-3
75-05-8 Acetonitrile 150 ppm
Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
Precautions for safe handling
No special precautions are necessary if used correctly.
Avoid breathing dust/fume/gas/mist/vapours/spray.
Avoid prolonged or repeated exposure.
Keep away from sources of ignition.
Take precautionary measures against static discharge.re.
Avoid breathing dust/fume/gas/mist/vapours/spray.
Avoid prolonged or repeated exposure.
Keep away from sources of ignition.
Take precautionary measures against static discharge.re.
Information about protection against explosions and fires
Keep ignition sources away - Do not smoke.
Protect against electrostatic charges.
Protect against electrostatic charges.
Conditions for safe storage, including any incompatibilities
Storage
Store in accordance with information listed on the product insert.
Requirements to be met by storerooms and receptacles
Store in a cool location.
Information about storage in one common storage facility
Not required.
Further information about storage conditions
Keep receptacle tightly sealed.
Store in cool, dry conditions in well sealed receptacles.
Store in cool, dry conditions in well sealed receptacles.
Specific end use(s)
No further relevant information available.
Control parameters
Components with limit values that require monitoring at the workplace:
The following constituent is the only constituent of the product which has a PEL, TLV or other recommended exposure limit.
At this time, the remaining constituent has no known exposure limits.
The following constituent is the only constituent of the product which has a PEL, TLV or other recommended exposure limit.
At this time, the remaining constituent has no known exposure limits.
| 75-05-8 Acetonitrile | |
|---|---|
| PEL | Long-term value: 70 mg/m³, 40 ppm |
| REL | Long-term value: 34 mg/m³, 20 ppm |
| TLV | Long-term value: 20 ppm Skin, A4 |
Additional information
The lists that were valid during the creation were used as basis.
Exposure controls
Appropriate engineering controls
No further data; see section 7.
Personal protective equipment
General protective and hygienic measures
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Avoid contact with the eyes.
Avoid contact with the eyes and skin.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Avoid contact with the eyes.
Avoid contact with the eyes and skin.
Breathing equipment
Not required.
Protection of hands
Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation
Material of gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application.
Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye protection
Tightly sealed goggles
Information on basic physicochemical properties
- Evaporation RateNot determined.
- Solids content0.1 %
- VOC content0.00 % 0.0 g/l / 0.00 lb/gal
- Danger of explosionProduct is not explosive. However, formation of explosive air/vapor mixtures are possible.
- Ignition temperatureProduct is not selfigniting.
- FormLiquid
- Particle characteristicsNot applicable.
- Vapor DensityNot determined.
- Relative Density1.36±0.1 g/cm3(Predicted)
- Density1.36±0.1 g/cm3(Predicted)
- Vapor Pressure at 50 °C (122 °F)330 hPa (247.5 mm Hg)
- Vapor Pressure at 20 °C (68 °F)98.6 hPa (74 mm Hg)
- Partition coefficient (n-octanol/water)Not determined.
- WaterFully miscible.
- Solubility in / Miscibility withAcetonitrile: Slightly Soluble: 0.1-1 mg/ml
Water: Slightly Soluble: 0.1-1 mg/ml - DynamicNot determined.
- SOLUBILITYAcetonitrile: Slightly Soluble: 0.1-1 mg/ml
Water: Slightly Soluble: 0.1-1 mg/ml - KinematicNot determined.
- pHNot determined.
- Decomposition temperatureNot determined.
- Auto igniting525 °C (977 °F)
- Flash point2 °C (35.6 °F)
- Explosion limitsLower: 4.4 Vol %
Upper: 16 Vol % - FlammabilityHighly flammable.
- Boiling point/Boiling range81 °C (177.8 °F)
- Melting point/Melting rangeUndetermined.
- FormulationA solution in water:acetonitrile
- Odor ThresholdNot determined.
- Molecular Weight370.5 g/mol
- Structural FormulaC20H34O6
- OdorCharacteristic
- ColorAccording to product specification
- Physical StateLiquid
Reactivity
No further relevant information available.
Chemical stability
Thermal decomposition / conditions to be avoided
No decomposition if used according to specifications.
Possibility of hazardous reactions
No dangerous reactions known.
Conditions to avoid
No further relevant information available.
Incompatible materials
No further relevant information available.
Hazardous decomposition products
No dangerous decomposition products known.
Information on toxicological effects
Acute toxicity
LD/LC50 values that are relevant for classification:
| Substance / Estimate | Route | Endpoint | Value |
|---|---|---|---|
| ATE (Acute Toxicity Estimate) | Oral | LD50 | 1,220 mg/kg (mouse) |
| ATE (Acute Toxicity Estimate) | Dermal | LD50 | 2,973 mg/kg (rabbit) |
| ATE (Acute Toxicity Estimate) | Inhalative | LC50/4 h | 21.1 mg/l |
| 75-05-8 Acetonitrile | Oral | LD50 | 617 mg/kg (mouse) (OECD Test Guideline 401) |
| 75-05-8 Acetonitrile | Dermal | LD50 | 1,500 mg/kg (rabbit) (Expert Judgement) Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) |
| 75-05-8 Acetonitrile | Inhalative | LC50/4 h | 6.022 mg/l (mouse) (OECD Test Guideline 403) |
| 4678-45-9 Grayanotoxin III | Intraperitoneal | TDLO | 0.015 mg/kg (rat) |
| 4678-45-9 Grayanotoxin III | Intraperitoneal | LD50 | 840 mg/kg (mouse) |
Primary irritant effect
on the skin
No irritant effect.
on the eye
Irritating effect.
Sensitization
No sensitizing effects known.
Additional toxicological information
The product shows the following dangers according to internally approved calculation methods for preparations
Harmful
Irritant
Harmful
Irritant
Interactive effects
No interactive effects between components are known.
Carcinogenic categories
IARC (International Agency for Research on Cancer)
None of the ingredients is listed.
NTP (National Toxicology Program)
None of the ingredients is listed.
OSHA-Ca (Occupational Safety & Health Administration)
None of the ingredients is listed.
Alternative sources for toxicological information
No non-standard sources for toxicological information where used.
Toxicity
Aquatic toxicity
No further relevant information available.
Persistence and degradability
No further relevant information available.
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Results of PBT and vPvB assessment
PBT
Not applicable.
vPvB
Not applicable.
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
Additional ecological information
General notes
Water hazard class 2 (Self-assessment) hazardous for water
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
Do not allow product to reach ground water, water course or sewage system.
Danger to drinking water if even small quantities leak into the ground.
Waste treatment methods
Recommendation
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
Uncleaned packagings
Recommendation
Disposal must be made according to official regulations.
Recommended cleansing agent
Water, if necessary with cleansing agents.
UN-Number
DOT, IMDG, IATA UN1993
UN proper shipping name
DOT Flammable liquids, n.o.s. (Acetonitrile)
IMDG FLAMMABLE LIQUID, N.O.S. (ACETONITRILE)
IATA Flammable liquid, n.o.s. (ACETONITRILE)
IMDG FLAMMABLE LIQUID, N.O.S. (ACETONITRILE)
IATA Flammable liquid, n.o.s. (ACETONITRILE)
Transport hazard class(es)
DOTClass: 3 Flammable liquids
Label: 3
IMDG, IATA
Label: 3
Class: 3 Flammable liquids
Label: 3
Label: 3
Packing group
DOT, IMDG, IATA II
Environmental hazards
Not applicable.
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
Transport/Additional information
DOT:
Quantity limitations
On passenger aircraft/rail: 5 L
On cargo aircraft only: 60 L
On cargo aircraft only: 60 L
IMDG:
Limited quantities (LQ)
1L
Excepted quantities (EQ)
Code: E2
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 500 ml
Maximum net quantity per inner packaging: 30 ml
Maximum net quantity per outer packaging: 500 ml
IATA:
Remarks
When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.
Special precautions for user
Warning: Flammable liquids
Hazard identification number (Kemler code)
33
EMS Number
F-E, S-E
Stowage Category
B
UN "Model Regulation"
UN 1993 FLAMMABLE LIQUID, N.O.S.
(ACETONITRILE), 3, II
(ACETONITRILE), 3, II
Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
Sara
| Section 355 (extremely hazardous substances): | None of the ingredients is listed. |
| Section 313 (Specific toxic chemical listings): | 75-05-8 Acetonitrile |
| TSCA (Toxic Substances Control Act): | 75-05-8 Acetonitrile ACTIVE |
| 7732-18-5 Water ACTIVE | |
| Hazardous Air Pollutants 75-05-8 Acetonitrile | |
| Chemicals known to cause cancer: | None of the ingredients is listed. |
| Chemicals known to cause reproductive toxicity for females: | None of the ingredients is listed. |
| Chemicals known to cause reproductive toxicity for males: | None of the ingredients is listed. |
| Chemicals known to cause developmental toxicity: | None of the ingredients is listed. |
Carcinogenic categories
| EPA (Environmental Protection Agency): |
75-05-8
Acetonitrile CBD, D
TLV (Threshold Limit Value)
75-05-8
Acetonitrile A4
NIOSH-Ca (National Institute for Occupational Safety and Health)
None of the ingredients is listed.
Chemical safety assessment
A Chemical Safety Assessment has not been carried out.
Abbreviations and acronyms
IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
ELINCS: European List of Notified Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
VOC: Volatile Organic Compounds (USA, EU)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Flammable liquids 2: Flammable liquids – Category 2
Acute toxicity - oral 4: Acute toxicity – Category 4
Eye irritation 2A: Serious eye damage/eye irritation – Category 2A
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
ELINCS: European List of Notified Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
VOC: Volatile Organic Compounds (USA, EU)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Flammable liquids 2: Flammable liquids – Category 2
Acute toxicity - oral 4: Acute toxicity – Category 4
Eye irritation 2A: Serious eye damage/eye irritation – Category 2A
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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