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(S)-(-)-PROPRANOLOL HYDROCHLORIDE

(S)-(-)-PROPRANOLOL HYDROCHLORIDE Structure
  • ₹12946.7 - ₹43451.55
  • Product name: (S)-(-)-PROPRANOLOL HYDROCHLORIDE
  • CAS: 4199-10-4
  • MF: C16H22ClNO2
  • MW: 295.8
  • EINECS:224-096-0
  • MDL Number:MFCD00064547
  • Synonyms:2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (2S)- (9CI);2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride, (S)-;L-(-)-Propranolol hydrochloride;l-Propranolol chlorhydrate;l-Propranolol hydrochloride;S-(-)-1-Isopropylamino-3-(1-naphthoxy)-2-propanol hydrochloride;S-PROPANOLOL;(S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 100MG
  • 500MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberP8688
  • Product description(S)-(−)-Propranolol hydrochloride ≥98% (TLC), powder
  • Packaging100MG
  • Price₹12946.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP8688
  • Product description(S)-(−)-Propranolol hydrochloride ≥98% (TLC), powder
  • Packaging500MG
  • Price₹43451.55
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) P8688 (S)-(−)-Propranolol hydrochloride ≥98% (TLC), powder 100MG ₹12946.7 2022-06-14 Buy
Sigma-Aldrich(India) P8688 (S)-(−)-Propranolol hydrochloride ≥98% (TLC), powder 500MG ₹43451.55 2022-06-14 Buy

Properties

Melting point :193-195 °C(lit.)
storage temp. :2-8°C
solubility :ethanol: 10 mg/mL
form :powder
color :White to off-white
optical activity :[α]25/D 25.5°, c = 1.0 in ethanol(lit.)
Water Solubility :Soluble to 100 mM in water
BRN :3574966
InChIKey :ZMRUPTIKESYGQW-UQKRIMTDSA-N
CAS DataBase Reference :4199-10-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Description

S(-)-Propranolol HCl is a small molecule β-adrenergic receptor antagonist and the active isomer of (±)-Propranolol preparations. S(-)-Propranolol HCl blocks the binding of epinephrine, norepinephrine, and other endogenous catecholamines to the β-adrenergic receptor, impeding increases in cardiac flow velocity and general stimulation of the sympathetic nervous system signaled by association of these molecules to the β-adrenergic receptor. In addition to blockade of agonist binding, antagonism of the β-adrenergic receptor by S(-)-Propranolol HCl produces negative chronotropic and inotropic action, effectively dampening the force and rate of cardiac contraction. These negative chronotropic and inotropic effects correlate to a demonstrated suppression of adrenaline-induced cardiac arrhythmia by S(-)-Propranolol HCl. Suppression of β-adrenergic receptor activation by S(-)-Propranolol HCl has been widely exploited in counteracting situations sensitive to heightened cardiac activity including hypertension, angina pectoris, and cardiac ischemia.

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