Saikosaponin D
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- Product name: Saikosaponin D
- CAS: 20874-52-6
- MF: C42H68O13
- MW: 780.99
- EINECS:
- MDL Number:MFCD09028095
- Synonyms:(3b,4a,16a)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-beta-D-glucopyranosyl beta-D-galactopyranoside;SAIKOSAPONIN D;saikosaponin ;saikosaponins ;Saikosaponian D;SAIKOSAPONIN D 98+% BY HPLC;SAILKOSAPONINS D;Saikosaponin d std.
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Properties
Melting point :212～218℃
Boiling point :893.7±65.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, Refrigerator, Under inert atmosphere
solubility :Methanol (Slightly), Pyridine (Slightly)
form :Solid
pka :12.83±0.70(Predicted)
color :White to Off-White
Stability :Hygroscopic
InChIKey :KYWSCMDFVARMPN-LPVIBIOGNA-N
LogP :3.756 (est)
CAS DataBase Reference :20874-52-6
Boiling point :893.7±65.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, Refrigerator, Under inert atmosphere
solubility :Methanol (Slightly), Pyridine (Slightly)
form :Solid
pka :12.83±0.70(Predicted)
color :White to Off-White
Stability :Hygroscopic
InChIKey :KYWSCMDFVARMPN-LPVIBIOGNA-N
LogP :3.756 (est)
CAS DataBase Reference :20874-52-6
Safety Information
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Description
Saikosaponin D is a triterpene saponin found in Bupleurum that exhibits antioxidative, immunomodulatory, anti-fibrotic, anti-angiogenic, anticancer, and chemopreventive activities. Saikosaponin D increases activity of superoxide dismutase, catalase, and glutathione peroxidase and decreases activity of malondialdehyde in cellular models of oxidative damage. In other in vitro models, saikosaponin D increases secretion of IL-12, maturation of dendritic cells, and proliferation of lymphocytes. Saikosaponin D inhibits SERCA, increasing intracellular Ca2+ and inducing autophagy. In vivo, this compound decreases severity of fibrosis. In embryos, saikosaponin D decreases microvessel formation. Additionally, this compound decreases tumor formation in DEN-treated animal models and suppresses expression of CEBP-β and COX-2. Saikosaponin D also induces apoptosis and activation of caspases 3 and 7 in hepatocellular carcinoma cells. Saikosaponin D is a Glucocorticoid receptor agonist. It is a COX-2 and iNOS inhibitor.More related product prices
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