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Sugammadex sodium

Sugammadex sodium Structure
  • ₹0
  • Product name: Sugammadex sodium
  • CAS: 343306-79-6
  • MF: C72H104Na8O48S8
  • MW: 2177.97
  • EINECS:200-838-9
  • MDL Number:MFCD09954145
  • Synonyms:ORG-25969/SugaMMadex;Sugammadex IMP;US-DMF No.: 033904 ASMF filed;6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,...;Sugammadex sodium (Org-25969);6 Sugammadex Sodium;Glucose-sodium;Sulgeng glucose sodium
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

storage temp. :Inert atmosphere,Room Temperature
solubility :DMF: 2.5 mg/ml; DMSO: 2.5 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml
form :A crystalline solid
color :White to off-white
Water Solubility :H2O: 2mg/mL, clear
InChIKey :NIOBYNJFPSIMJF-OBHNVPISNA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P285 In case of inadequate ventilation wear respiratory protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P341 IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P330 Rinse mouth.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P501 Dispose of contents/container to..…

Description

To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.

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Suppliers and manufacturers

BTC pharm India Lofty labs Mankind Pharma Limited Solara Active Pharma Sciences Ltd Medchem Labs Ralington Pharma Gland Pharma Ltd Mac Chem Products (India) Pvt Ltd (Naprod Group) Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd) Apicore Pharmaceuticals Pvt Ltd