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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Pancreatic hormone and blood sugar regulation >TOLAZAMIDE

TOLAZAMIDE

TOLAZAMIDE Structure
  • ₹0
  • Product name: TOLAZAMIDE
  • CAS: 1156-19-0
  • MF: C14H21N3O3S
  • MW: 311.4
  • EINECS:214-588-3
  • MDL Number:MFCD00083504
  • Synonyms:1-(hexahydro-1-azepinyl)-3-p-tolylsulfonylurea ;1-(hexahydro-1h-azepin-1-yl)-3-(p-tolylsulfonyl)-ure ;1-(hexahydro-1h-azepin-1-yl)-3-(p-tolylsulfonyl)urea ;4-(p-tolylsulfonyl)-1,1-hexamethylenesemicarbazide ;Tolazamide Solution, 100ppm;diabewas ;n-(((hexahydro-1h-azepin-1-yl)-amino)carbonyl)-4-methyl-benzenesulfonamid ;n-(p-toluenesulfonyl)-n’-hexamethyleniminourea
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :162-164°C
Boiling point :300°C (rough estimate)
Density :1.2228 (rough estimate)
refractive index :1.6740 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Very slightly soluble in water; freely soluble in chloroform; soluble in acetone; slightly soluble in ethanol (96%).
form :Solid
pka :3.6(at 25℃)
color :White to Off-White
Water Solubility :65.4mg/L(30 ºC)
InChI :InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)
InChIKey :OUDSBRTVNLOZBN-UHFFFAOYSA-N
SMILES :C1(S(NC(NN2CCCCCC2)=O)(=O)=O)=CC=C(C)C=C1
CAS DataBase Reference :1156-19-0(CAS DataBase Reference)
EPA Substance Registry System :Tolazamide (1156-19-0)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 μM in HEK293 cells transfected with the human receptor). It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration of 0.6 mg/mL but enhances glucose uptake two-fold when used in combination with insulin. In vivo, tolazamide (128 mg/kg) reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes induced by streptozotocin . Formulations containing tolazamide have been used in the treatment of type 2 diabetes.

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Suppliers and manufacturers

Shaanxi Dideu Medichem Co. Ltd
TOLAZAMIDE
₹0.10 /1KG
TOLAZAMIDE CAS:1156-19-0
career henan chemical co
TOLAZAMIDE
₹1.00 /1g
TOLAZAMIDE CAS:1156-19-0
TargetMol Chemicals Inc.
Tolazamide
₹48.00 /5mg
Tolazamide CAS:1156-19-0
CLEARSYNTH LABS LTD. A.J Chemicals Pharmaffiliates Analytics and Synthetics P. Ltd Triveni chemicals
ATK CHEMICAL COMPANY LIMITED
Hefei TNJ Chemical Industry Co.,Ltd.
Zhejiang J&C Biological Technology Co.,Limited