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Tolbutamide-d9

Tolbutamide-d9 Structure
  • ₹0
  • Product name: Tolbutamide-d9
  • CAS: 1219794-57-6
  • MF: C12H18N2O3S
  • MW: 270.35
  • EINECS:
  • MDL Number:
  • Synonyms:1-(Butyl-3-(p-tolyl- sulfonyl)urea-d9;3-(p-Tolyl-4-sulfonyl)-1-butylurea-d9;Artosin-d9;Artozin-d9;Mobenol-d9;N-[(ButylaMino-d9)carbonyl]-4-MethylbenzenesulfonaMide;N-Butyl-N'-(4-Methylphenylsulfonyl)urea-d9;Tolylsulfonylbutylurea-d9
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :108-111°C
storage temp. :Refrigerator
solubility :DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/ml
form :A solid
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 μM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 μM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.

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Suppliers and manufacturers

CLEARSYNTH LABS LTD. Pharmaffiliates Analytics and Synthetics P. Ltd Cayman Chemical Company Shanghai EFE Biological Technology Co., Ltd. LGC Science (Shanghai) Ltd. Absin Bioscience Inc. Cayman Chemical Company Santa Cruz Biotechnology Inc Alta Scientific Co., Ltd. Shenzhen Polymeri Biochemical Technology Co., Ltd.