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ChemicalBook >> CAS DataBase List >> Isotretinoin

Isotretinoin

Isotretinoin price.
  • $10 - $1767.15
  • Product name: Isotretinoin
  • CAS: 4759-48-2
  • MF: C20H28O2
  • MW: 300.44
  • EINECS:225-296-0
  • MDL Number:MFCD00079542
  • Synonyms:Isotretinoin-D5/13-cis-Retinoic acid-D5;Roaccutan;(2Z,4E,6E,8E)-3,7-diMethyl-9-(2,6,6-triMethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid;A different diMension acid;Isotretinoin API;(2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid Isotretinoin;Isotretinoin (Roaccutane);Isotretinoin (EP5.0)
54 prices
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Brand
  • Adipogen Life Sciences
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
  • Usbiological
Package
  • 10mM(in 1mL DMSO)
  • 50mg
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  • i0800000
  • 100MG
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  • 3x100mg
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  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3709-M050
  • Product descriptionIsotretinoin ≥98%
  • Packaging50mg
  • Price$25
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3709-M250
  • Product descriptionIsotretinoin ≥98%
  • Packaging250mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ61666
  • Product description13-cis-Retinoic acid
  • Packaging500mg
  • Price$238.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA181906
  • Product description(2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoicacid 98%(HPLC)
  • Packaging25g
  • Price$79
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA181906
  • Product description(2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoicacid 98%(HPLC)
  • Packaging100g
  • Price$244
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003050
  • Product descriptionISOTRETINOIN 95.00%
  • Packaging100MG
  • Price$173.25
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0027420
  • Product description13-CIS-RETINOIC ACID 95.00%
  • Packaging5MG
  • Price$459.14
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003050
  • Product descriptionISOTRETINOIN 95.00%
  • Packaging500MG
  • Price$704.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0003050
  • Product descriptionISOTRETINOIN 95.00%
  • Packaging5G
  • Price$1767.15
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4330
  • Product descriptionIsotretinoin
  • Packaging100mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4330
  • Product descriptionIsotretinoin
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS466525
  • Product descriptionIsotretinoin 98%
  • Packaging50mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS466525
  • Product descriptionIsotretinoin 98%
  • Packaging100mg
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS466525
  • Product descriptionIsotretinoin 98%
  • Packaging250mg
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS466525
  • Product descriptionIsotretinoin 98%
  • Packaging1g
  • Price$37
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS466525
  • Product descriptionIsotretinoin 98%
  • Packaging5g
  • Price$73
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3709-M050 Isotretinoin ≥98% 50mg $25 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3709-M250 Isotretinoin ≥98% 250mg $100 2021-12-16 Buy
Alfa Aesar J61666 13-cis-Retinoic acid 500mg $238.65 2024-03-01 Buy
Ambeed A181906 (2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoicacid 98%(HPLC) 25g $79 2021-12-16 Buy
Ambeed A181906 (2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoicacid 98%(HPLC) 100g $244 2021-12-16 Buy
American Custom Chemicals Corporation API0003050 ISOTRETINOIN 95.00% 100MG $173.25 2021-12-16 Buy
American Custom Chemicals Corporation API0027420 13-CIS-RETINOIC ACID 95.00% 5MG $459.14 2021-12-16 Buy
American Custom Chemicals Corporation API0003050 ISOTRETINOIN 95.00% 500MG $704.55 2021-12-16 Buy
American Custom Chemicals Corporation API0003050 ISOTRETINOIN 95.00% 5G $1767.15 2021-12-16 Buy
ApexBio Technology A4330 Isotretinoin 100mg $42 2021-12-16 Buy
ApexBio Technology A4330 Isotretinoin 10mM(in 1mL DMSO) $50 2021-12-16 Buy
Arctom AS466525 Isotretinoin 98% 50mg $10 2021-12-16 Buy
Arctom AS466525 Isotretinoin 98% 100mg $12 2021-12-16 Buy
Arctom AS466525 Isotretinoin 98% 250mg $16 2021-12-16 Buy
Arctom AS466525 Isotretinoin 98% 1g $37 2021-12-16 Buy
Arctom AS466525 Isotretinoin 98% 5g $73 2021-12-16 Buy

Properties

Melting point :172-175 °C (lit.)
Boiling point :381.66°C (rough estimate)
Density :1.0597 (rough estimate)
refractive index :1.4800 (estimate)
storage temp. :-20°C
solubility :Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent). It is sensitive to air, heat and light, especially in solution. Carry out all operations as rapidly as possible and avoid exposure to actinic light; use freshly prepared solutions.
pka :4.76±0.33(Predicted)
form :Fine Crystalline Powder
color :Yellow-orange to orange
Water Solubility :insoluble
λmax :354nm(EtOH)(lit.)
Merck :14,5228
Stability :Stable, but probably air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
InChIKey :SHGAZHPCJJPHSC-YCNIQYBTSA-N
CAS DataBase Reference :4759-48-2(CAS DataBase Reference)
EPA Substance Registry System :Isotretinoin (4759-48-2)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Isotretinoin is the 9-cis isomer of retinoic acid, a close relative of retinol, or vitamin A. It was originally developed to treat cystic acne, and today this is still its primary use despite several more modern applications of the drug, including a treatment for pancreatic and brain cancers. First shown to be an effective treatment for acne in 1982, its development stemmed from advances in knowledge of the effects of vitamin A to reduce or eliminate sebum production. Since that time, however, several instances of deleterious effects became well known, most notably birth defects arising from the use of isotretinoin.

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