英夫利昔单抗
| 中文名称 | 英夫利昔单抗 |
|---|---|
| 中文同义词 | INFLIXIMAB ( 英利昔单抗 );英夫利单抗;英夫利昔单抗(INFLIXIMAB)?主营 |
| 英文名称 | Infliximab |
| 英文同义词 | Avakine;Immunoglobulin G, anti-(human tumor necrosis factor) (human-mouse monoclonal ca2 heavy chain), disulfide with human-mouse monoclonal ca2 light chain, dimer;Remicade;Unii-B72hh48flu;CT-P 13;Infliximab USP/EP/BP;Research Grade Infliximab(DHB94403);TNFR1,Infliximab,anti-inflammatory,Avakine,Tumor Necrosis Factor Receptor,autoimmune,diabetic,TNFR,PTP1B,neuropathy,Inhibitor,TNFR2,monoclonal,TNF Receptor,inhibit,CT-P13 |
| CAS号 | 170277-31-3 |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | 单抗12;对照品;化学试剂 |
| Mol文件 | Mol File |
| 结构式 |
英夫利昔单抗 性质
| 储存条件 | Store at -30°C |
|---|
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TNF-α
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TNF-α-treated adipocytes shows a significant 64% decrease in insulin-stimulated glucose uptake, whereas Infliximab (10 ng/mL) reverses TNF-α actions by significantly improving glucose incorporation in 3T3L1 adipocytes. Infliximab restores phosphorylation of substrate-2 and AKT by attenuating protein-tyrosine phosphatase 1B (PTP1B) activation. Infliximab ameliorates TNF-α-induced insulin resistance in 3T3L1 adipocytes in vitro by restoring the insulin signalling pathway via PTP1B inhibition.
A single injection of Infliximab (10 μg/g in 100 μl saline/dose ip) in diabetic TNF-α +/+ ) mice leads to suppression of the increased serum TNF-α and amelioration of the electrophysiological and biochemical deficits for at least 4 weeks. The increased TNF-α mRNA expression in diabetic dorsal root ganglion is also attenuated by Infliximab.