氢溴酸非诺特罗
| 中文名称 | 氢溴酸非诺特罗 |
|---|---|
| 中文同义词 | 氢溴酸芬忒醇;氢溴酸非诺特罗;甲醇中菲诺特罗溶液标准物质;氢溴酸非诺特罗非诺特罗 氢溴酸盐;5-[1-羟基-2-[[2-(4-羟基苯基)-1-甲基乙基]氨基]乙基]-1,3-苯二醇;氢溴酸菲诺特罗;氢溴酸菲诺特罗标准溶液;氢溴酸非诺特罗/酚丙喘宁芬忒醇 |
| 英文名称 | FENOTEROL HYDROBROMIDE |
| 英文同义词 | FENOTEROL HBR;FENOTEROL HYDROBROMIDE;2-[3,5-DIHYDROXYPHENYL]-2-HYDROXY-2'-[4-HYDROXYPHENYL]-1'-METHYLDIETHYLAMINE HYDROBROMIDE;1-(3,5-dihydroxy-phenyl)-2-((1-(4-hydroxybenzyl)ethyl)amino)-ethanolhydrobro;berotec;berotechydrobromide;fenoterolbromide;partusisten |
| CAS号 | 1944-12-3 |
| 分子式 | C17H22BrNO4 |
| 分子量 | 384.26 |
| EINECS号 | 217-742-8 |
| 相关类别 | 分析标准品;瘦肉精类;法医和兽医标准品;医药原料;标准品;对照品;Amines;Aromatics;Adrenoceptor;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 1944-12-3.mol |
| 结构式 |  |
氢溴酸非诺特罗 性质
| 熔点 | 226-228°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 溶于水和乙醇（96%）。 |
| 颜色 | 白色至类白色 |
Fenoterol hydrobromide (Phenoterol)是fenoterol的氢溴酸盐。Fenoterol是β2 adrenoreceptor激动剂，具有支气管扩张活性。
| Target | Value |
|
β2 adrenoreceptor
() |
Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.
Western Blot Analysis
| Cell Line: | THP-1 cells stimulated with AICAR |
| Concentration: | 1 μM |
| Incubation Time: | Pre-incubated 30 minutes |
| Result: | Significantly downregulated the elevated phosphorylation levels of AMPK. |
Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.
| Animal Model: | Male C57BL/6J mice (6 weeks old) with neuropathy |
| Dosage: | 0.7 mg/kg |
| Administration: | Intraperitoneal injection; twice a day; for 3 weeks |
| Result: | Alleviated neuropathic allodynia during chronic treatment. |
用途
校准仪器和装置；评价方法；工作标准；质量保证/质量控制安全信息
| 提供商 | 语言 |
|---|---|
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英文
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