盐酸美加明
| 中文名称 | 盐酸美加明 |
|---|---|
| 中文同义词 | 盐酸美加敏;美加明;N,2,3,3-四甲基双环[2.2.1]庚-2-胺盐酸盐;异坎胺;盐酸美加明;盐酸美卡拉明;盐酸美加明 USP标准品;美加明-[13C4,15N] 盐酸盐 |
| 英文名称 | Mecamylamine hydrochloride |
| 英文同义词 | N,2,3,3-TETRAMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE;inversine;mevasinhydrochloride;n,2,3,3-tetramethyl-2-norbornanaminehydrochloride;n,2,3,3-tetramethyl-2-norbornanaminhydrochloride;n-methyl-dl-isobornylaminehydrochloride;Mecamylamine HCl;MECAMYLAMINE USP |
| CAS号 | 826-39-1 |
| 分子式 | C11H22ClN |
| 分子量 | 203.75 |
| EINECS号 | 212-555-8 |
| 相关类别 | 小分子抑制剂;合成;小分子抑制剂，天然产物;化学试剂;医药原料;Acetylcholine receptor;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;有机化工原料;医用原料;对照品 |
| Mol文件 | 826-39-1.mol |
| 结构式 |  |
盐酸美加明 性质
| 熔点 | >240°C (dec.) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 乙醇：122 mg/mL |
| 酸度系数(pKa) | pKa 11.2(H2O,t undefined,I=0.1) (Uncertain) |
| 稳定性 | 吸湿性 |
| CAS 数据库 | 826-39-1(CAS DataBase Reference) |
| EPA化学物质信息 | Bicyclo[2.2.1]heptan-2-amine, N,2,3,3-tetramethyl-, hydrochloride (1:1) (826-39-1) |
nAChR
Mecamylamine blocks muscle nAChRs in a use- and voltagedependent manner. Mecamylamine blocks the nicotinic currents via trapping mechanism. The main feature of this block is the phenomenon of block relief, which might be revealed by combined action of depolarization and activation of nAChRs. The experimental study of the Mecamylamine action on muscle nAChRs revealed that: (1) Mecamylamine (1-20 μM) reduces evoked end-plate currents (EPC) amplitude with Hill’s constant equal to 1.2 and IC 50 = 7.8 μM at holding potential –70 mV; (2) the calculated depth of its interaction with the muscle nAChR channel is almost half of the one of neuronal nAChRs (0.37 compare to 0.72 for neuronal nAChRs); (3) simultaneous membrane depolarization and repetitive activation of postsynaptic nAChRs by motor nerve stimulation produced rapid block relief dependent on the degree of depolarization, number of conditioning signals and Mecamylamine concentration, and only slightly depended on the rate of stimulation.
Mecamylamine (0.5-1 mg/kg; Intraperitoneal injection; C57BL/6J mice) has antidepressant-like effects in both the TST and FST and these effects are dependent on bothβ2 andα7 subunits.
| Animal Model: | C57BL/6J mice (3-4 months) forced swim test (FST) and tail suspension test (TST) |
| Dosage: | 0.5 mg/kg, 0.75 mg/kg, 1 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Significantly decreased immobility time in the TST at the 1.0-mg/kg dose but did not alter baseline locomotor activity. Also significantly decreased time immobile in the FST. |
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22-36/37/38 |
| 安全说明 | 36/37/39 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS号 | RB6900000 |
| 危险等级 | 6.1 |
| 海关编码 | 2921300000 |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B1395 | Mecamylamine hydrochloride | 1 mg | 280元 | |
| 2024/01/25 | HY-B1395 | 盐酸美加明 Mecamylamine hydrochloride | 826-39-1 | 5mg | 700元 |