ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2
中文名称 | ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2 |
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中文同义词 | 胡蜂蜂毒肽 7;黃蜂毒素MASTOPARAN 7;胡蜂蜂毒肽 7,≥97% (HPLC) |
英文名称 | MAS 7 |
英文同义词 | ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2;H-ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2;INLKALAALAKALL-NH2;19: PN: WO2010069074 SEQID: 17 claimed protein;MASTOPARAN 7;MAS 7;MASTOPARAN 7 SYNTHETIC >98%;mastoparan from polistes jadwagae |
CAS号 | 145854-59-7 |
分子式 | C67H124N18O15 |
分子量 | 1421.81 |
EINECS号 | |
相关类别 | 细胞生物学;细胞信号和神经生物学;标准品;G-Protein;Peptide;Phospholipase Activators;Lipids in Cell Signaling;Phospholipid Metabolism |
Mol文件 | 145854-59-7.mol |
结构式 |
ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2 性质
沸点 | 1649.9±65.0 °C(Predicted) |
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密度 | 1.154±0.06 g/cm3(Predicted) |
储存条件 | -20°C |
形态 | 冻干粉 |
酸度系数(pKa) | 13.43±0.46(Predicted) |
Mas7 (Mastoparan 7) produces several biological effects in different cell types. The effect of Mas7 on endogenous mono-ADP-ribosyltransferase activity is in the micromolar range with a maximal activation of 205% over the basal. In pertussis treated plasma membranes, it is found that the effect of Mas7 on endogenous mono-ADP-ribosyltransferase is partially blocked, which suggests the involvement of G-proteins, such as Gi or G0.
Mas7 is a basic tetradecapeptide isolated from isp venom, which activates guanine nucleotide-binding regulatory proteins (G-proteins) and stimulates apoptosis. In smooth muscle cells, Mas7 leads to an increase in the perfusion pressure. Vascular contraction is induced by Mas7. The vasoconstriction triggered by mas-7 exhibited a slower increase compared to that simulated by phenylephrine or vasopressin.
Exposure of hippocampal neurons to a low dose of Mas-7 increases dendritic spine density and spine head width in a time-dependent manner. Additionally, Mas-7 enhances postsynaptic density protein-95 (PSD-95) clustering in neurites and activates Gαo signaling, increasing the intracellular Ca
2+
concentration.
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-P0258 | ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2 Mas7 | 145854-59-7 | 1mg | 900元 |
2024/01/25 | HY-P0258 | ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2 Mas7 | 145854-59-7 | 5mg | 3600元 |