广藿香酮
| 中文名称 | 广藿香酮 |
|---|---|
| 中文同义词 | 4-羟基-6-甲基-3-(4-甲基-1-氧代戊基)-2H-吡喃-2-酮;广霍香酮(广藿香酮);广藿香酮(标准品);POGOSTONE 广藿香酮;广霍香酮;广藿香酮(分析标准品);异香附酮;广藿香酮对照品 |
| 英文名称 | DHELWANGIN |
| 英文同义词 | DHELWANGIN;4-Hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-2H-pyran-2-one;4-Hydroxy-6-methyl-3-(4-methylpentanoyl)-2H-pyran-2-one;2H-Pyran-2-one,4-hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-;Autophagy,Apoptosis,Inhibitor,Pogostone,Bacterial,gram positive,gram negative,inhibit,corynebacterium xerosis |
| CAS号 | 23800-56-8 |
| 分子式 | C12H16O4 |
| 分子量 | 224.25 |
| EINECS号 | |
| 相关类别 | 标准品;中药对照品;对照品;分析试剂标准品;对照品-中药对照品;其它酚类;标准品 -中药标准品;标准品，对照品;医药、农药及染料中间体 |
| Mol文件 | 23800-56-8.mol |
| 结构式 |  |
广藿香酮 性质
| 沸点 | 348.2±42.0℃ (760 Torr) |
|---|---|
| 密度 | 1.185±0.06 g/cm3 (20 ºC 760 Torr) |
| 闪点 | 129.9±21.4℃ |
| 储存条件 | 4°C, protect from light |
| 溶解度 | DMF：1.6mg/mL；二甲基亚砜：3mg/mL；乙醇：3mg/mL；乙醇:PBS (pH 7.2) (1:5): 0.16mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 5.27±0.50(Predicted) |
| LogP | 0.750 (est) |
IC50: apoptosis; autophagy; bacteria
Pogostone shows inhibitory effects on HCT116 cell with an IC 50 value of 18.7±1.93 µg/ml, and show strikingly lower cytotoxicity on normal human embryonic kidney cell 293A (IC 50 : 95.13±19.44 µg/ml) and endothelial cell HUVEC (IC 50 : 112±20.77 µg/ml).
Pogostone ( intraperitoneal injection; 25, 50 and 100 mg/kg) shows antibacterial activity in vivo against Escherichia coli (E. coli) and MRSA. Ninety percent of the mice infected with E. coil could be protected at the concentrations of 50 and 100 mg/kg, and 60% of the mice at 25 mg/kg, while the rate of protection for the mice infected with MRSA was 60% and 50% at doses of 100 and 50 mg/kg, respectively.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/16 | S9094 | 广藿香酮 Pogostone | 23800-56-8 | 1mg | 876.69元 |