AKT 激酶抑制剂
| 中文名称 | AKT 激酶抑制剂 |
|---|---|
| 中文同义词 | AKT 激酶抑制剂;AKT抑制剂(AKT KINASE INHIBITOR);化合物 T10276;3-(2-(4-氨基-1,2,5-恶二唑-3-基)-7-(3-氨基丙氧基)-1-乙基-1H-咪唑并[4,5-C]吡啶-4-基)丙-2-炔-1-醇 |
| 英文名称 | AKT Kinase Inhibitor |
| 英文同义词 | AKT Kinase Inhibitor;3-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-propyn-1-ol;2-Propyn-1-ol, 3-[2-(4-aMino-1,2,5-oxadiazol-3-yl)-7-(3-aMinopropoxy)-1-ethyl-1H-iMidazo[4,5-c]pyridin-4-yl]-;AKT Kinase Inhibitor (2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-);3-[2-(4-amino-1;5-c]pyridin-4-yl]-;5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4;AKT Kinase Inhibitor USP/EP/BP |
| CAS号 | 842148-40-7 |
| 分子式 | C16H19N7O3 |
| 分子量 | 357.37 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;中药对照品 |
| Mol文件 | 842148-40-7.mol |
| 结构式 |  |
AKT 激酶抑制剂 性质
| 沸点 | 678.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.50 |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO : 16.67 mg/mL (46.65 mM; 需要超声波)H2O : < 0.1 mg/mL (不溶) |
| 形态 | 粉末 |
| 酸度系数(pKa) | 12.98±0.10(Predicted) |
AKT Kinase Inhibitor 是一种具有抗肿瘤活性的 Akt 抑制剂。
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Akt
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The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.
Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-10249A | AKT 激酶抑制剂 AKT Kinase Inhibitor | 842148-40-7 | 5mg | 3500元 |
| 2024/01/25 | HY-10249A | AKT 激酶抑制剂 AKT Kinase Inhibitor | 842148-40-7 | 10mM * 1mLin DMSO | 3850元 |