| 公司名称： |
上海波以尔化工有限公司 |
| 联系电话： |
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| 产品介绍： |
英文名称:PX478 2HCl
CAS:685898-44-6
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| 公司名称： |
BOC Sciences |
| 联系电话： |
16316197922 |
| 产品介绍： |
英文名称:PX-478
CAS:685898-44-6
纯度：>98% |
| 公司名称： |
Wuhan NCE Biomedical Co.,Ltd. |
| 联系电话： |
4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988 |
| 产品介绍： |
英文名称:PX-478 dihydrochloride
CAS:685898-44-6
纯度：99% HPLC 包装信息：50Mg,100Mg,500Mg,1g,5g,10g,50g,100g,500g,1kg 备注：XYA0472 |
| 公司名称： |
上海皓元医药股份有限公司 |
| 联系电话： |
86-21-58998985 |
| 产品介绍： |
英文名称:PX-478
CAS:685898-44-6
纯度：>98% 包装信息：900RMB/5mg 备注：试剂级 |
| 公司名称： |
上海常丰生物医药科技有限公司 |
| 联系电话： |
13611721451 021-61727342 |
| 产品介绍： |
英文名称:PX478
CAS:685898-44-6
包装信息：1g,5g,10g,25g,100g,500g,1kg 备注：定制产品 |
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| 中文名称: | N/A | | 中文同义词: | | | 英文名称: | L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) | | 英文同义词: | L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2);PX-478 dihydrochloride;PX478 2HCl;4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine,hydrochloride (1:2);PX-478 HCl;Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2);4-[Bis(2-chloroethyl)oxidoamino]-L-phenylalanine dihydrochloride;(S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride | | CAS号: | 685898-44-6 | | 分子式: | C13H20Cl4N2O3 | | 分子量: | 394.13 | | EINECS号: | | | 相关类别: | | | Mol文件: | 685898-44-6.mol |  |
| 生物活性 | PX-478 2HCl是一种具有口服活性的选择性hypoxia-inducible factor-1α (HIF-1α)抑制剂。Phase 1。 | | 体外研究 | PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells. | | 体内研究 | In HT-29 human colon cancer xenografts, PX-478 suppresses HIF-1alpha levels and inhibits the expression of HIF-1 target genes including vascular endothelial growth factor and the glucose transporter-1. In addition, PX-478 (100 or 120 mg/kg i.p.) also shows antitumor activity including cures against several established human tumor xenografts that is related to the levels of HIF-1α. In high-fat-diet mice, PX-478 causes reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues. |
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