没食子酸甲酯
| 中文名称 | 没食子酸甲酯 |
|---|---|
| 中文同义词 | 没食子酸甲酯;3,4,5-三羟基苯甲酸甲酯;3,4,5-三羟基苯甲酸甲酯,98%;电子级没食子酸甲酯(99.9%,MG);3,4,5-三羟基苯甲酸甲酯酯/没食子酸甲酯;棓酸甲酯,五棓子酸甲酯,3,4,5-三羟基苯甲酸甲酯;没食子酸甲脂;3,4,5-三羟基苯甲酸甲酯, 98.0%(GC&T |
| 英文名称 | Methyl gallate |
| 英文同义词 | 3,4,5-trihydroxybenzoic acid methyl ester (intermediate of bifendate);METHYL GALLATE(METHYL 3,4,5-TRIHYDROXYBENZOATE );METHYLGALLATE(RG);2-diazo-1-naphthol-5-sulfonic acid, ester with novolac;METHYGALLATE;3,4,5-trihydroxy-benzoic acidd methyl ester;METHYL 3,4,5-TRIHYDROXYBENZOATE / METHYL GALLATE;Gallic acid methyl ester, Methyl 3,4,5-trihydroxybenzoate |
| CAS号 | 99-24-1 |
| 分子式 | C8H8O5 |
| 分子量 | 184.15 |
| EINECS号 | 202-741-7 |
| 相关类别 | 羰基化合物;中药对照品;细胞生物学;植物提取物;标准品;对照品;医药中间体;其他生化试剂;化学试剂;细胞信号和神经生物学;工业原料;生化试剂;化工;没食子酸甲酯;其他原料;Photo Active Compounds;Aromatic Esters;Organic acids;(intermediate of bifendate);Food additive ,Antioxidant anticorrosive;分析试剂标准品;生化试剂-其他化学试剂;有机化工原料;化工原料;对照品-中药对照品;其它酚类;化工原料-1827181813;有机中间体;化工中间体工业原料;标准品，对照品;精细化工原料;添加剂;有机化工原料;通用生化试剂-有机酸;香精香料 |
| Mol文件 | 99-24-1.mol |
| 结构式 |  |
没食子酸甲酯 性质
| 熔点 | 201-204 °C |
|---|---|
| 沸点 | 278.08°C (rough estimate) |
| 密度 | 1.3840 (rough estimate) |
| 折射率 | 1.5690 (estimate) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 乙醇：50 mg/mL，澄清 |
| 形态 | 结晶粉末 |
| 酸度系数(pKa) | 8.04±0.23(Predicted) |
| 颜色 | 白色至略带米色 |
| 水溶解性 | SOLUBLE IN HOT WATER |
| Merck | 14,4345 |
| BRN | 2113180 |
| InChIKey | FBSFWRHWHYMIOG-UHFFFAOYSA-N |
| LogP | 0.860 |
| CAS 数据库 | 99-24-1(CAS DataBase Reference) |
| EPA化学物质信息 | Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1) |
没食子酸甲酯通过抑制CD4+CD25+调节性T细胞的浸润表现出强大的抗肿瘤活性。
Methyl gallate是具有抗氧化，抗癌和抗炎活性的植物酚类。Methyl gallate也可抑制细菌活性。Methyl gallate 还具有抗 HIV-1 和 HIV-1 酶的抑制活性。Bacterial
The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL). Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H 2 O 2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H 2 O 2 (8.0 mM) for a 3 h period. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate.
安全信息
| 危险品标志 | Xn,Xi |
|---|---|
| 危险类别码 | 22-36/37/38-43 |
| 安全说明 | 26-36/37-24/25 |
| WGK Germany | 3 |
| RTECS号 | LW8000000 |
| TSCA | Yes |
| 海关编码 | 29182900 |
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