PI-3065
| 中文名称 | PI-3065 |
|---|---|
| 中文同义词 | 6-[[4-(环丙基甲基)-1-哌嗪基]甲基]-2-(5-氟-1H-吲哚-4-基)-4-(4-吗啉基)噻吩并[3,2-D]嘧啶;4-(6-((4-(环丙基甲基)哌嗪-1-基)甲基)-2-(5-氟-1H-吲哚-4-基)噻吩并[3,2-D]嘧啶-4-基)吗啉;化合物CH5132799;PI 3065,PI 3-激酶P110Δ抑制剂 |
| 英文名称 | PI-3065 |
| 英文同义词 | PI-3065;6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine;PI-3065|PI3065;4-(6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine;6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine;6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine PI-3065;PI-3065, >=98%;6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine |
| CAS号 | 955977-50-1 |
| 分子式 | C27H31FN6OS |
| 分子量 | 506.64 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂，天然产物;小分子抑制剂;Inhibitors |
| Mol文件 | 955977-50-1.mol |
| 结构式 |  |
PI-3065 性质
| 密度 | 1.372±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMSO 中≥22.7 mg/mL；不溶于水；不溶于乙醇 |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.80±0.30(Predicted) |
| CAS 数据库 | 955977-50-1 |
PI-3065是一种选择性p110δ抑制剂，IC50为15 nM,选择性比其他PI3K家族成员高出70多倍。PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ.In mouse model, PI-3065 (75 mg/kg, p.o.) also suppresses 4T1 tumor growth and metastasis via inactivation of p110δ. In the LSL.KrasG12D/+; p53R172H/+; PdxCretg/+ (or KPC) model of pancreatic ductal adenocarcinoma, PI-3065 prolongs survival and reduces the incidence of macroscopic metastases and other disease-associated pathologies.
|
p110α 910 nM (IC 50 ) |
p110β 600 nM (IC 50 ) |
p110δ 5 nM (IC 50 ) |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-12235 | PI-3065 | 955977-50-1 | 2mg | 800元 |
| 2024/01/25 | HY-12235 | PI-3065 | 955977-50-1 | 5mg | 1200元 |