1-(2-噻唑基偶氮)-2-萘酚
| 中文名称 | 1-(2-噻唑基偶氮)-2-萘酚 |
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| 中文同义词 | 1-(2-噻唑基偶氮)-2-萘酚;1-(2-噻唑偶氮)-2-萘酚;1-(2'-噻唑基偶氮)-2-萘酚;2-(2-羟基-1-萘基偶氮)噻唑;1-(2-联氮噻吩)-2-萘酚;1-(2’-噻唑偶氮)-2-萘酚;TAN[=1-(2-噻唑偶氮)-2-萘酚][过渡金属类用分光光度试剂];TAN[=1-(2-噻唑偶氮)-2-萘酚](>99.0%(T)) |
| 英文名称 | 1-(2-THIAZOLYLAZO)-2-NAPHTHOL |
| 英文同义词 | TAN;2-(2-Hydroxy-1-naphthylazo)thiazole, TAN;Nitrilotantalum(III);1-(Thiazole-2-ylazo)-2-naphthol;1-(Thiazole-2-ylazo)naphthalene-2-ol;1-[(Thiazole-2-yl)azo]-2-naphthol;TAN [=1-(2-Thiazolylazo)-2-naphthol];TAN [=1-(2-Thiazolylazo)-2-naphthol] [Spectrophotometric reagent for transition metals] |
| CAS号 | 1147-56-4 |
| 分子式 | C13H9N3OS |
| 分子量 | 255.3 |
| EINECS号 | 214-555-3 |
| 相关类别 | 试剂和补充物;Analytical Chemistry;Azo Compounds;Chelating Reagents;Naphthylazo Compounds |
| Mol文件 | 1147-56-4.mol |
| 结构式 |  |
1-(2-噻唑基偶氮)-2-萘酚 性质
| 熔点 | 138-139 °C |
|---|---|
| 沸点 | 464.8±47.0 °C(Predicted) |
| 密度 | 1.40 |
| 储存条件 | 2-8°C |
| 溶解度 | 在甲醇中可溶10 mg/mL，澄清 |
| 酸度系数(pKa) | 8.71±0.50(Predicted) |
| 形态 | 固体 |
| 颜色 | 红色或橙色 |
| BRN | 223783 |
| 稳定性 | 可在-20°C下的DMSO溶液保存长达1个月。 |
| CAS 数据库 | 1147-56-4(CAS DataBase Reference) |
| EPA化学物质信息 | 2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4) |
IC50: 30 to 400 nM (ERG-positive cancer cells)
NSC139021 selectively inhibits growth of ERGpositive cancer cell lines with minimal effect on normal prostate or endothelial cells or ERG-negative tumor cell lines. The IC 50 of NSC139021 for cell growth inhibition of responsive cell lines range between 30 nM to 400 nM. Combination of NSC139021 with enzalutamide shows additive effects in inhibiting growth of VCaP cells. A screen of kinases reveal that NSC139021 directly bound the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature.
NSC139021 treatment inhibits growth of ERG-positive VCaP tumor xenografts with no apparent toxicity. Significant (P<0.05, P<0.005) inhibition of tumor growth is noted at day 26 in treatment groups indicating 44% (100 mg/kg) and 65% (150 mg/kg) reduction of tumor burden. At 100 mg/kg and 150 mg/kg, no apparent toxicity including weight loss, lethargy, diarrhea, loss of appetite, respiratory distress, or overall drug related toxicity is observed. .
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