优降宁盐酸盐

优降宁盐酸盐

中文名称优降宁盐酸盐
中文同义词盐酸帕吉林;巴吉林,优降宁;巴吉林盐酸盐,丙炔甲基苄胺,巴吉林;巴吉林盐酸盐,丙炔甲基苄胺,帕吉林,巴吉林;N-甲基-N-2-丙炔基苄胺 盐酸盐;N-甲基-N-丙炔基苄胺 盐酸盐;优降宁 盐酸盐;N-甲基-N-炔丙基苄胺盐酸盐
英文名称PARGYLINE HYDROCHLORIDE
英文同义词N-METHYL-N-PROPARGYLBENZYLAMINE HYDROCHLORIDE;N-METHYL-N-(2-PROPYNY)BENZYLAMINE HYDROCHLORIDE;N-METHYL-N-2-PROPYNYLBENZYLAMINE HYDROCHLORIDE;PARGYLINE HYDROCHLORIDE;benzylmethylpropynylaminehydrochloride;n-benzyl-n-methyl-2-propynylaminehydrochloride;n-benzyl-n-methyl-2-propynylaminhydrochloride;n-methyl-n-2-propynyl-benzylaminhydrochloride
CAS号306-07-0
分子式C11H14ClN
分子量195.69
EINECS号206-175-1
相关类别小分子抑制剂;细胞信号和神经生物学;细胞生物学;细胞生物学试剂;日用化学品;标准品;试剂
Mol文件306-07-0.mol
结构式优降宁盐酸盐 结构式

优降宁盐酸盐 性质

熔点160-163 °C(lit.)
储存条件-20°C
溶解度乙醇中≥33.55 mg/mL;水中≥51.6 mg/mL; ≥7.55 mg/mL,溶于 DMSO
形态结晶固体
颜色从EtOH/Et2O结晶的晶体
Merck13,7110
BRN3699487
InChIKeyBCXCABRDBBWWGY-UHFFFAOYSA-N
CAS 数据库306-07-0

优降宁盐酸盐 用途与合成方法

Pargyline hydrochloride 是一种不可逆的单胺氧化酶 (MAO) 抑制剂,对 MAO-A 和 MAO-B 的 Ki 分别为 13 μM 和 0.5 μM。Pargyline hydrochloride 具有降压和抗癌活性。
TargetValue
MAO-B
(Cell-free assay)
0.5 μM(Ki)
MAO-A
(Cell-free assay)
13 μM(Ki)

Pargyline (0.5-2 mM; 24-120 hours; LNCaP-LN3 cells) treatment inhibits the proliferation of prostate cancer cells in a time- and dose-dependent manner.
Pargyline (0.5-2 mM; 24-48 hours; LNCaP-LN3 cells) treatment decreases S phase and increases the G1 phase in the cells in a dose-dependent manner.
Pargyline (0.5 mM; 24 hours; LNCaP-LN3 cells) treatment increases the apoptotic cells.
Pargyline (2 mM; 48 hours; LNCaP-LN3 cells) treatment induces an increase of cytochrome c and a decrease of caspase-3 in the cells, but does not lead to a change of BCL-2 expression.

Cell Proliferation Assay

Cell Line: LNCaP-LN3 cells
Concentration: 0.5 mM, 1 mM, 1.5 mM or 2 mM
Incubation Time: 24 hours, 48 hours, 72 hours, 96 hours or 120 hours
Result: Inhibited the proliferation of prostate cancer cells in a time- and dose-dependent manner.

Cell Cycle Analysis

Cell Line: LNCaP-LN3 cells
Concentration: 0.5 mM, 2 mM
Incubation Time: 24 hours, 48 hours
Result: The S phase ratio of the cells was decreased, while their G1 phase ratio was increased.

Apoptosis Analysis

Cell Line: LNCaP-LN3 cells
Concentration: 0.5 mM
Incubation Time: 24 hours
Result: Increased the apoptotic cells.

Western Blot Analysis

Cell Line: LNCaP-LN3 cells
Concentration: 2 mM
Incubation Time: 48 hours
Result: Induced an increase of cytochrome c and a decrease of caspase-3.

Pargyline (10 mg/kg; iv) treatment induces a moderate (about 20 mm Hg) but persistent (48 h) decrease of systolic blood pressure in unanesthetized adult spontaneously hypertensive rats (SHR) but not in normotensive rats.
A low dose of Pargyline (200 μg; icv) injected directly into the brain lowered arterial pressure. The hypotensive action of Pargylline in SHR appears to be the consequence of Norepinephrine accumulating at an inhibitory α-adrenoceptor in brain.

用途 
具有明显的降压作用,单胺氧化酶(MAO-B)选择性抑制剂。
类别
有毒物品
毒性分级
高毒
急性毒性
口服-大鼠 LD50: 142 毫克/公斤; 口服-小鼠 LD50; 680 毫克/公斤
可燃性危险特性
可燃;燃烧产生有毒氮氧化物和氯化氢烟雾;药物副作用:影响心理状态;影响液体吸收
储运特性
通风低温干燥; 与库房食品原料分开存放
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水

安全信息

危险品标志Xn
危险类别码22
安全说明22-24/25
危险品运输编号UN 2811 6.1/PG 3
WGK Germany3
RTECS号DP6650000
F10
危险等级6.1(b)
包装类别III
海关编码2921199990
毒性LD50 orl-rat: 250 mg/kg 27ZQAG -,401,72

MSDS信息

提供商 语言
英文
更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-A0091Pargyline hydrochloride100 mg290元
2024/01/25HY-A0091巴吉林,优降宁
Pargyline hydrochloride
306-07-010mM * 1mLin DMSO319元

优降宁盐酸盐 上下游产品信息

"优降宁盐酸盐"相关产品信息
优降糖D3 优降宁 苯甲胺盐酸盐 优降宁盐酸盐 N-(4-氯-2-丁基)酞亚酸
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