LY310762
| 中文名称 | LY310762 |
|---|---|
| 中文同义词 | 1-[2-[4-(4-氟苯甲酰基)-1-哌啶基]乙基]-1,3-二氢-3,3-二甲基-2H-吲哚-2-酮盐酸盐;1-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-3,3-二甲基吲哚啉-2-酮盐酸盐;化合物LY310762;LY310762,5-HT1拮抗剂 |
| 英文名称 | LY310762 |
| 英文同义词 | 1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-onehydrochloride;LY 310762 HCl;1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-diMethylindolin-2-one Hydrochloride;2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-diMethyl-, Monohydrochloride;LY310762;LY-310762;3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one hydrochloride;LY-310,762 HYDROCHLORIDE;1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one,hydrochloride |
| CAS号 | 192927-92-7 |
| 分子式 | C24H27O2N2FHCl |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂，天然产物;神经信号;小分子抑制剂;Inhibitors |
| Mol文件 | 192927-92-7.mol |
| 结构式 |  |
LY310762 性质
| 储存条件 | Sealed in dry,Room Temperature |
|---|---|
| 溶解度 | DMSO：可溶10 mg/mL 加热 |
| 形态 | 白色粉末 |
| CAS 数据库 | 192927-92-7 |
LY310762是一种5-HT1D受体拮抗剂，Ki为249 nM，对5-HT1B受体具有较低的亲和力。LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. The maximum potentiation of the potassium-induced outflow which is obtained with LY310762 is about 40%. LY310762 blocks the decreased EPSC amplitude induced by Sumatriptan.Systemic administration of LY310762 (10 mg/kg i.p.) produces a further significant enhancement in the 5-HT response to fluoxetine (20 mg/kg i.p.) when compared to animals receiving a control vehicle injection. In fluoxetine treated animals, levels of 5-HT increases from 312±43% to a maximum of 683% after LY310762. In control animals, levels of 5-HT remains unchanged (250%). LY310762 administered alone also significantly increases basal levels of 5-HT above vehicle controls, reaching a maximum of 258% compared to the pre-injection control.
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5-HT 1D Receptor 249 nM (Ki) |
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英文
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