4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺
中文名称 | 4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺 |
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中文同义词 | 4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺(组蛋白去乙酰化酶抑制剂);组蛋白去乙酰化酶抑制剂(M 344);4-二甲基氨基-N-(6-羟基氨基甲酰己基)苯甲酰胺;4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺;化合物HISTONE DEACETYLASE INHIBITOR III;4-(二甲氨基)-N-(7-羟基氨基-7-氧代庚基)苯甲酰胺 |
英文名称 | M344 |
英文同义词 | M344;HISTONE DEACETYLASE INHIBITOR III;4-DIMETHYLAMINO-N-(6-HYDROXYCARBAMOYLHEXYL)-BENZAMIDE;N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE;4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, MS 344, D237, N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide;4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide;MS 344;M 344 (enzyme inhibitor) |
CAS号 | 251456-60-7 |
分子式 | C16H25N3O3 |
分子量 | 307.39 |
EINECS号 | |
相关类别 | 小分子抑制剂;小分子抑制剂,天然产物;细胞骨架信号;细胞生物学试剂;标准品;Amines;Aromatics;Inhibitors;Apoptosis Inducers;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitor |
Mol文件 | 251456-60-7.mol |
结构式 |
4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺 性质
熔点 | 161℃ |
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密度 | 1.137±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO:可溶10mg/mL,澄清 |
酸度系数(pKa) | 9.48±0.20(Predicted) |
形态 | 白色固体 |
颜色 | 白色至米色 |
敏感性 | Light Sensitive |
CAS 数据库 | 251456-60-7 |
HDAC 100 nM (IC 50 ) |
M344 is a potential histone deacetylase (HDAC) inhibitor. BRCA1 mRNA levels are determined by RT-PCR following exposure to increasing concentrations of the HDAC inhibitor M344 alone and in combination with Cisplatin in all 6 cell lines evaluated in this study. With increasing concentrations of M344, there is a dose dependant decrease in BRCA1 mRNA and treatment with both 1 and 5 μM concentrations of M344 resulting in a significant decrease in BRCA1 expression in all cell lines examined. M344 in combination with Cisplatin leads to a decrease in BRCA1 mRNA expression as compared to Cisplatin treatment alone in all cell lines with the exception of A2780s, which is recognized as having potent cytotoxicity to Cisplatin. In the MCF7 cell line, BRCA1 is down regulated at physiological doses of M344 (0.5 μM and 1 μM) but M344 does not have the same inhibitory effect on BRCA1 at the 5.0 μM dose. Co-treatment with Cisplatin and increasing concentrations of M344 reduces BRCA1 protein levels in all breast and ovarian cell lines examined.
安全信息
WGK Germany | 3 |
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海关编码 | 2928.00.2500 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-13506 | 4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺 M344 | 251456-60-7 | 5mg | 810元 |
2024/08/19 | HY-13506 | 4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺 M344 | 251456-60-7 | 10mM * 1mLin DMSO | 891元 |