4-羟基三苯氧胺
中文名称 | 4-羟基三苯氧胺 |
---|---|
中文同义词 | 4-羟基三苯氧胺(Z异构体和E异构体);4-羟基三苯氧胺(Z异构体≥70%);4-羟基三苯氧胺 10MG;(Z)-4-(1-[4-(二甲氨基乙氧基)苯基]-2-苯基-1-丁烯基)苯酚;(Z)-4-羟基三苯氧胺;4-羟基三苯氧胺(Z异构体);4-羟基三苯氧胺(Z异构体≥7;4-羟基三苯氧胺(Z异构体和E |
英文名称 | 4-HYDROXYTAMOXIFEN |
英文同义词 | trans-4-Hydroxytamoxifen, (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol;(Z)-3,4-Diphenyl-4-[4-[2-(dimethylamino)ethoxy]phenyl]-3-buten-1-ol;2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine;4-[(E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol;cis-4-Hydroxytamoxifen;N,N-Dimethyl-2-[4-[(E)-1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]ethanamine;TAMOXIFEN 4-HYDROXY, (E) AND (Z) ISOMERS (50:50);(Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol |
CAS号 | 68047-06-3 |
分子式 | C26H29NO2 |
分子量 | 387.51 |
EINECS号 | |
相关类别 | 生化试剂;抗生素;Aromatics;Metabolites & Impurities;Drug Analogues;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids |
Mol文件 | 68047-06-3.mol |
结构式 |
4-羟基三苯氧胺 性质
熔点 | 105-107°C |
---|---|
沸点 | 513.45°C (rough estimate) |
密度 | 1.1005 (rough estimate) |
折射率 | 1.6000 (estimate) |
储存条件 | 2-8°C |
溶解度 | 95%乙醇:20 mg/mL |
酸度系数(pKa) | 10.35±0.15(Predicted) |
形态 | 粉末 |
颜色 | 白色 |
稳定性 | 稳定的。存放干燥通风处。与强氧化剂不相容。 |
InChIKey | TXUZVZSFRXZGTL-OCEACIFDSA-N |
CAS 数据库 | 68047-06-3 |
Estrogen receptor 3.3 nM (IC 50 ) |
CRISPR/Cas9
|
4-Hydroxytamoxifen (Monohydroxytamoxifen) is a selective oestrogen receptor antagonist, with an IC 50 of 3.3 nM for the [ 3 H]oestradiol binding to oestrogen receptor. 4-Hydroxytamoxifen (10, 100 nM) enables to inhibit the binding of [ 3 H]oestradiol to the human 8 S oestrogen receptor. 4-Hydroxytamoxifen activates intein-linked inactive Cas9, reduces off-target CRISPR-mediated gene editing. In human cells, conditionally active Cas9s modify target genomic sites with up to 25-fold higher specificity than wild-type Cas9.
4-Hydroxytamoxifen (0.2, 1 and 5 μg/day, p.o.) causes a dose-related decrease in uterine wet weight of immature rats. 4-Hydroxytamoxifen (6 μg/0.1 mL sesame oil/day, s.c.) effectively attenuates methamphetamine-induced nigrostriatal dopamine depletions in bothsexes of intact and gonadectomized C57BL/6 J mice. 4-Hydroxytamoxifen does not alter the dopamine content levels in the striatum.
安全信息
危险品标志 | Xn |
---|---|
危险类别码 | 20/21/22-63 |
安全说明 | 22-23-36 |
WGK Germany | 3 |
RTECS号 | SL1210000 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-16950 | 4-羟基三苯氧胺 4-Hydroxytamoxifen | 68047-06-3 | 10mM * 1mLin DMSO | 639元 |
2024/08/19 | HY-16950 | 4-羟基三苯氧胺 4-Hydroxytamoxifen | 68047-06-3 | 5 mg | 750元 |