澳洲茄边碱
| 中文名称 | 澳洲茄边碱 |
|---|---|
| 中文同义词 | 澳洲茄边碱(标准品);边缘茄碱;澳洲茄边碱(奥洲边茄碱);澳州茄边碱;澳洲茄边碱, >98%;Α-奥洲边茄碱;Α-SOLAMARGINE;(-)-澳洲茄边碱 |
| 英文名称 | Solamargine |
| 英文同义词 | SOLAMERGINE;δ-Solanigrine;2)-O-[6-deoxy-a-L-Mannopyranosyl-(1®b-D-Glucopyranoside, (3b,22a,25R)-spirosol-5-en-3-yl O-6-deoxy-a-L-Mannopyranosyl-(1®(3β,22α,25R)-Spirosol-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1→2)-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside;[(22R,25R)-Spirosola-5-ene-3β-yl]2-O,4-O-bis(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside;(3beta,22alpha,25R)-spirosol-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-4)]-beta-D-glucopyranoside;NSC 407810 |
| CAS号 | 20311-51-7 |
| 分子式 | C45H73NO15 |
| 分子量 | 868.06 |
| EINECS号 | |
| 相关类别 | 植物提取物;对照品;植提标准品;中药对照品;标准品;Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;标准品 -中药标准品;标准品，对照品 |
| Mol文件 | 20311-51-7.mol |
| 结构式 |  |
澳洲茄边碱 性质
| 熔点 | 301 °C |
|---|---|
| 密度 | 1.38 |
| 储存条件 | Refrigerator |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 12?+-.0.70(Predicted) |
| 颜色 | 浅米色低熔点 |
澳洲茄边碱是从茄属植物中分离得到的一种甾体生物碱。澳洲茄边碱可以与c3样蛋白酶(SARS-CoV-2主蛋白酶)的氨基酸Phe8、Pro9、Ile152、Tyr154、Pro293、Phe294、Val297和Arg298相互作用。其来源于龙葵SolanumnigrumL.果实；丁茄SolanumsurattenseBurm.f，有散瘀消肿，止痛拔毒的作用。Solamargine 是一种来源于茄属植物的类固醇 Solasodine 的衍生物，在多种癌症中均表现出抗癌活性。Solamargine 诱导非选择性细胞毒性和 P-gp 抑制作用。Solamargine 通过下调 MMP-2 和 MMP-9 的表达和活性来显着抑制 HepG2 细胞的迁移和侵袭。
药理药效:牛皮癣、皮肤瘙痒及多种癌症治疗
Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis.
Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC
50
s are 9.21 and 19.88 μg/ml, respectively.
Cell Viability Assay
| Cell Line: | SMMC-7721cells |
| Concentration: | 15 μg/ml |
| Incubation Time: | 72 hours |
| Result: | Displayed a significant increase of sub-G1. |
Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo.
| Animal Model: | Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old) |
| Dosage: | 10 mg/kg |
| Administration: | Intragastric administration; once daily for 8 days |
| Result: | Tumor growth was significantly inhibited . |
化学性质
白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于澳洲茄 Solanum aviculare Forst.果实。用途
澳洲茄边碱具有治疗牛皮癣、皮肤瘙痒的作用。用途
用于含量测定/鉴定/药理实验等。药理药效:牛皮癣、皮肤瘙痒及多种癌症治疗