2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺
| 中文名称 | 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 |
|---|---|
| 中文同义词 | 2-溴-2-(2-氟苯基)-1-环丙乙酮;2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺;化合物INDIBULIN;INDIBULIN,微管去稳定剂 |
| 英文名称 | Indibulin |
| 英文同义词 | Nascapine;ZIO 301;2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide;Indibulin;2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;lindiblin;2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide;1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl- |
| CAS号 | 204205-90-3 |
| 分子式 | C22H16ClN3O2 |
| 分子量 | 389.83 |
| EINECS号 | |
| 相关类别 | 标准品;Anticancer. |
| Mol文件 | 204205-90-3.mol |
| 结构式 |  |
2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 性质
| 密度 | 1.31±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | DMSO：33.25（最大浓度 mg/mL）；85.29（最大浓度 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.38±0.70(Predicted) |
Indibulin (ZIO 301, D 24851, Zybulin) 是一种口服的 tubulin assembly 抑制剂，并具有有效的抗癌活性。Indibulin 可诱导有丝分裂的停滞和凋亡。
| Target | Value |
|
Tubulin
() |
Indibulin (300-2100 nM; 48 hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150 nM.
Indibulin (300, 600 nM; 48 hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis.
Indibulin (150-600 nM; 24 hours) induces apoptosis in MCF-7 cells.
Indibulin (150-600 nM; 48 hours) with 300 and 600 nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells.
Cell Proliferation Assay
| Cell Line: | MCF-7 cells |
| Concentration: | 300, 600, 900, 1200, 1500, 1800, 2100 nM |
| Incubation Time: | 48 hours |
| Result: | Inhibited the proliferation of MCF-7 cells with an IC 50 of 150 nM. |
Cell Cycle Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 300, 600 nM |
| Incubation Time: | 48 hours |
| Result: | Blocked the cells in the G2/M phase of the cell cycle. |
Apoptosis Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 150, 300 and 600 nM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in MCF-7 cells. |
Western Blot Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 150, 300 and 600 nM |
| Incubation Time: | 48 hours |
| Result: | Generated cleaved fragments of PARP protein in 300 and 600 nM. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-13649 | 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 Indibulin | 204205-90-3 | 5mg | 700元 |
| 2024/01/25 | HY-13649 | 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺 Indibulin | 204205-90-3 | 10mM * 1mLin DMSO | 770元 |