香橙素
| 中文名称 | 香橙素 |
|---|---|
| 中文同义词 | 二氢莰非醇;香橙素,香树素;香橙素(标准品);二氢山奈酚;二氢化萜醇;香橙素(二氢山奈酚 );二氢山柰酚;(2R,3R)-3,5,7-三羟基-2-(4-羟基苯基)四氢苯并吡喃-4-酮 |
| 英文名称 | DIHYDROKAEMPFEROL |
| 英文同义词 | 3,5,7,4'-TETRAHYDROXYFLAVANONE;DIHYDROKAEMPFEROL;(2R)-2,3-Dihydro-3β,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;(2R,3R)-2,3-Dihydro-2-(4-hydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one;DIHYDROKAEMPFEROL-CMPD;(2R,3R)-2,3- Dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;AroMadendrin (DihydrokaeMpferol);(2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chroMen-4-one |
| CAS号 | 480-20-6 |
| 分子式 | C15H12O6 |
| 分子量 | 288.25 |
| EINECS号 | 687-473-2 |
| 相关类别 | 标准品;植物提取物;分析试剂标准品;对照品;标准品 -对照药材;黄酮;对照品;Flavanones |
| Mol文件 | 480-20-6.mol |
| 结构式 |  |
香橙素 性质
| 熔点 | 237～241℃ |
|---|---|
| 沸点 | 139-140 °C |
| 密度 | 1.599±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | DMSO:2.88(最大浓度 mg/mL);10.0(最大浓度 mM) |
| 酸度系数(pKa) | 7.42±0.60(Predicted) |
| InChIKey | PADQINQHPQKXNL-LSDHHAIUSA-N |
| LogP | 2.860 (est) |
| EPA化学物质信息 | 4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R,3R)- (480-20-6) |
Dihydrokaempferol 是从紫荆花 Bauhinia championii (Benth) 中分离得到的。 Dihydrokaempferol 诱导 apoptosis 并抑制 Bcl-2 和 Bcl-xL 的表达。Dihydrokaempferol 可以作为抗关节炎新药的良好候选。
Apoptosis; Bcl-2; Bcl-xL
Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs. Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively). Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP.
Cell Proliferation Assay
| Cell Line: | Normal synoviocyte cells; RA-FLS cells |
| Concentration: | 0.3 μM, 3 μM, 30 μM, 300 μM |
| Incubation Time: | 48 hours |
| Result: | Decreased the proliferation of RA-FLSs. |
Apoptosis Analysis
| Cell Line: | RA-FLS cells |
| Concentration: | 3 μM, 30 μM |
| Incubation Time: | 48 hours |
| Result: | Induced apoptosis in RA-FLSs. |
Western Blot Analysis
| Cell Line: | RA-FLS cells |
| Concentration: | 3 μM, 30 μM |
| Incubation Time: | 48 hours |
| Result: | Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N2897 | Dihydrokaempferol | 1 mg | 571元 | |
| 2024/01/25 | HY-N2897 | 香橙素 Dihydrokaempferol | 480-20-6 | 5mg | 1500元 |