WARANGALONE
中文名称 | WARANGALONE |
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中文同义词 | 攀登鱼藤异黄酮 |
英文名称 | warangalone |
英文同义词 | warangalone;5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-10-(3-methylbut-2-en-1-yl)pyrano[3,2-g]chromen-4(8H)-one;5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one;Scandenolone;2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one,5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methyl-2-buten-1-yl)-;Warangalone (Scandenolone);5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)-6-pyrano[3,2-g][1]benzopyranone |
CAS号 | 4449-55-2 |
分子式 | C25H24O5 |
分子量 | 404.46 |
EINECS号 | |
相关类别 | 标准品;植物提取物;标准品 -对照药材;黄酮 |
Mol文件 | 4449-55-2.mol |
结构式 |
WARANGALONE 性质
熔点 | 164-165 °C |
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沸点 | 627.0±55.0 °C(Predicted) |
密度 | 1.258±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
酸度系数(pKa) | 6.39±0.40(Predicted) |
颜色 | 浅黄至黄色 |
IC50: 4.8 μg/mL (3D7), 3.7 μg/mL (K1)
IC50: 3.5 μM (cAK)
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC 50 s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC 50 of 3.5 μM. When HL-60 cells are exposed to Warangalone (30 μM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N1074 | WARANGALONE Warangalone | 4449-55-2 | 1mg | 3341元 |