苦木素
| 中文名称 | 苦木素 |
|---|---|
| 中文同义词 | 苦木素;苦味素;QUASSIN (~90%);QUASSIN (>95%);苦木苦素,苦木素 |
| 英文名称 | QUASSIN |
| 英文同义词 | Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy-;QUASSINPOWDER;QUASSIN;11,16-trione,2,12-dimethoxy-picrasa-12-diene-1;(3aS,6aR,7aS,8S,11aS,11bS,11cS)-1,3a,4,5,6a,7,7a,8,11,11a,11b,11c-dodecahydro-2,10-dimethoxy-3,8,11a;(3As,6ar,7as,8S,11as,11bs,11cs)-1,3A,4,5,6A,7,7A,8,11,11A,11B,11C-dodecahydro-2,10-dimethoxy-3,8,11A,11C-tetramethyldibenzo(de,G)chromene-1,5,11-trione;2,12-Dimethoxypicrasa-2,12-diene-1,11,16-trione;Einecs 200-985-9 |
| CAS号 | 76-78-8 |
| 分子式 | C22H28O6 |
| 分子量 | 388.45 |
| EINECS号 | 200-985-9 |
| 相关类别 | 植物提取物;标准品;标准品 -中药标准品;二萜;营养强化剂 |
| Mol文件 | 76-78-8.mol |
| 结构式 |  |
苦木素 性质
| 熔点 | 222° |
|---|---|
| 比旋光度 | D20 +34.5° (c = 5.09 in CHCl3) |
| 沸点 | 586.3±50.0 °C(Predicted) |
| 密度 | 1.23±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C Freezer, Under inert atmosphere |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| LogP | 2.220 (est) |
| EPA化学物质信息 | Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy- (76-78-8) |
Quassin (Nigakilactone D) 是一种从 Quassia amara 的茎皮提取物中提取的生物活性三萜。Quassin 抑制 P. falciparum，IC50 为 0.15 μM。Quassin 具有可逆的抗生育能力，抗雌激素和抗疟原虫活性。
IC50: 0.15 μM ( P. falciparum )
Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion.
Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats.
| Animal Model: | 35 females albino rats (150-170 g) |
| Dosage: | 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg |
| Administration: | Oral administration; daily; for 60 days |
| Result: | There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats. |
用途
Quassin is a naturally occurring extract from quassia trees and is used in traditional chinese medicine for it鈥檚 antiulcerogenic properties. Quassin have also been used as an additive in soft drinks.