盐酸罗沙替丁醋酸酯
中文名称 | 盐酸罗沙替丁醋酸酯 |
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中文同义词 | 2-乙酰氧基-N-[3-[3-(1-哌啶基甲基苯)氧基]丙基]乙酰胺盐酸盐;盐酸罗沙替丁醋酸酯;罗沙;ROXATIDINE ACETATE HCL 盐酸罗沙替丁醋酸酯;罗沙替丁醋酸氢氯化物;盐酸罗沙替丁醋酸脂;罗沙替丁醋酸酯盐酸盐;盐酸罗沙替丁醋酸酯(93793-83-0) |
英文名称 | Roxatidine acetate hydrochloride |
英文同义词 | ROXATIDINE HCL ACETATE;2-(acetyloxy)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-acetamidmonoh;2-acetoxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)acetamidehydrochloride;2-hydroxy-n-(3-(m-(piperidinomethyl)phenoxy)propyl)-acetamidacetate(ester;2-hydroxy-n-(3-(m-(piperidinomethyl)phenoxy)propyl)acetamideacetate(ester);aceroxatidinehydrochloride;acetamide,2-hydroxy-n-(3-(m-(1-piperidinylmethyl)phenoxy)propyl)-,acetate,;tzu0460 |
CAS号 | 93793-83-0 |
分子式 | C19H29ClN2O4 |
分子量 | 384.89756 |
EINECS号 | 685-494-1 |
相关类别 | 小分子抑制剂;神经信号;对照品;原料;中药对照品;原料药;Miscellaneous Biochemicals;Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;MEFOXIN;Other APIs;杂质对照品;医药原料;日用化学品;化学试剂;Pharmaceuticals;API |
Mol文件 | 93793-83-0.mol |
结构式 |
盐酸罗沙替丁醋酸酯 性质
熔点 | 145-146° |
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储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
溶解度 | DMSO:78mg/mL;乙醇:12mg/mL;水:77mg/mL |
形态 | 粉末晶体 |
颜色 | 白色到近乎白色 |
Merck | 14,8274 |
Target | Value |
Histamine H2 receptor | 3.2 μM |
Roxatidine Acetate Hydrochloride (6.25 μM, 12.5 μM, and 25 μM; pre-treatment for 30 min) suppresses the PMACI-induced activation of p38 MAPK, but does not affect the phosphorylation of ERK or JNK. The total ERK 1/2, JNK, and p38 MAPK levels are unaffected by roxatidine in human mast-cells-1 (HMC-1) cells.
Roxatidine Acetate Hydrochloride (oral gavage; 20 mg/kg; single dose) inhibits Compound 48/80-increased TNF-α, IL-6, and IL-1β production and mRNA expression. Additionally, Roxatidine decreases the compound 48/80-induced degradation of procaspase-1 and appearance of the corresponding cleaved bands in mice.
Animal Model: | ICR male mice (6 weeks old) |
Dosage: | 20 mg/kg |
Administration: | Oral gavage; 20 mg/kg; single dose |
Result: | Suppressed compound 48/80-induced allergic inflammation in anaphylactic animal model. |
安全信息
RTECS号 | AC3855000 |
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海关编码 | 2933.39.9200 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-B0305A | 盐酸罗沙替丁醋酸酯 Roxatidine Acetate Hydrochloride | 93793-83-0 | 500mg | 600元 |
2024/01/25 | HY-B0305A | 盐酸罗沙替丁醋酸酯 Roxatidine Acetate Hydrochloride | 93793-83-0 | 10mM * 1mLin DMSO | 660元 |