奥克太尔
| 中文名称 | 奥克太尔 |
|---|---|
| 中文同义词 | 奥克生太;奥克太尔;间酚嘧啶;化合物 T0323L |
| 英文名称 | OXANTEL |
| 英文同义词 | OXANTEL;3-[(E)-2-(1,4,5,6-Tetrahydro-1-methylpyrimidin-2-yl)vinyl]phenol;CP-14445-16;Telopar;(E)-3-(2-(1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinyl)vinyl)phenol;3-[(E)-2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol;Phenol, 3-[(1E)-2-(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)ethenyl]-;OXANTEL USP/EP/BP |
| CAS号 | 36531-26-7 |
| 分子式 | C13H16N2O |
| 分子量 | 216.28 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 36531-26-7.mol |
| 结构式 |  |
奥克太尔 性质
| 沸点 | 383.1±52.0 °C(Predicted) |
|---|---|
| 密度 | 1.09±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.42±0.10(Predicted) |
Oxantel (CP-14445) 是 Pyrantel (HY-12641) 的衍生物，是 N-亚型的 AChR 激动剂。Oxantel 是一种驱虫剂，具有优良驱虫活性。
nAChR
Oxantel ( 0.015-600 µg/mL; 24-72 hours) reduces the viability of
T. muris
.
Cell Viability Assay
| Cell Line: | T. muris |
| Concentration: | 0.015 µg/mL, 0.3 µg/mL, 0.6 µg/mL, 4.66 µg/mL, 9.375 µg/mL, 150 µg/mL, 600 µg/mL |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Resulted in strongly reduced viabilities; resulted in strongly reduced viabilities within 24 hours but did not kill the worms. |
Oxantel (1-10 mg/kg; i.p.) displays a high activity against
T. muris
in vivo, with an EC
50
of 4.71 mg/kg.
Oxantel (10 mg/kg; i.p.) exhibits a worm burden reduction (WBR) of 92.5% and worm expulsion rate (WER) of 88.4% for
T. muris
.
| Animal Model: | 4 week-old female C57BL/10 mice and 3 week-old male |
| Dosage: | 1 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Inhibited T. muris in vivo. |