异长叶烯
| 中文名称 | 异长叶烯 |
|---|---|
| 中文同义词 | (-)-异长叶烯;异长叶烯;(2S)-1,3,4,5,6,7-六氢-1,1,5,5-四甲基-2H-2,4A-亚甲基萘;(1R)-2,2,7,7-四甲基三环[6.2.1.01.6]十一-5-烯;异长叶烯(甄准不供应);异长(松)叶烯;化合物BIKININ;(-)-异长叶烯 |
| 英文名称 | Isolongifolene |
| 英文同义词 | (-)-Isolongifolene >=98.0% (suM of enantioMers, GC);(-)-Isolongifoline;(2s)-1,3,4,5,6,7-hexahydro-1,1,5,5;(2s)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2h-2,4a-methanonaphthalene;2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-;C15 H24, 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S)-;ISOLONGIFOLENE(SG);(2s)-2h-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-4a-methanonaphthalen |
| CAS号 | 1135-66-6 |
| 分子式 | C15H24 |
| 分子量 | 204.35 |
| EINECS号 | 214-494-2 |
| 相关类别 | 香精香料;植物提取物;标准品;原料;香精与香料咨询13026126800;有机化工原料;其他原料;化工原料;单体香料;有机原料 |
| Mol文件 | 1135-66-6.mol |
| 结构式 |  |
异长叶烯 性质
| 沸点 | 255-256 °C |
|---|---|
| 密度 | 0.930 g/mL at 20 °C(lit.) |
| 蒸气压 | 5.49Pa at 25℃ |
| 折射率 | n |
| 闪点 | 49°C |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：10 mg/mL（48.94 mM） |
| 气味 (Odor) | 木质、尘土、琥珀香 |
| 香型 | woody |
| 旋光性 (optical activity) | [α]20/D 138±2°, c = 1% in ethanol |
| 水溶解性 | 59.998μg/L at 25℃ |
| BRN | 2207559 |
| LogP | 5.77 at 25℃ |
| CAS 数据库 | 1135-66-6(CAS DataBase Reference) |
| NIST化学物质信息 | 2H-2,4a-methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2s)-(1135-66-6) |
| EPA化学物质信息 | 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)- (1135-66-6) |
Isolongifolene ((-)-Isolongifolene) 是一种从 Murraya koenigii 中分离的三环倍半萜烯。Isolongifolene 通过调节 P13K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激，线粒体功能障碍和细胞凋亡。Isolongifolene 具有抗氧化，抗炎，抗癌和神经保护的特性。
Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene.
Cell Viability Assay
| Cell Line: | SH-SY5Y neuroblastoma cells |
| Concentration: | 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM |
| Incubation Time: | 26 hours |
| Result: | Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. |
Apoptosis Analysis
| Cell Line: | SH-SY5Y neuroblastoma cells |
| Concentration: | 10 µM |
| Incubation Time: | 26 hours |
| Result: | Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. |
Western Blot Analysis
| Cell Line: | SH-SY5Y neuroblastoma cells |
| Concentration: | 10 µM |
| Incubation Time: | 26 hours |
| Result: | Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β. |
用途
是制造具有木香香气的合成香料异长叶烷酮和异长叶甲酸酯的主要原料安全信息
| 危险类别码 | 10 |
|---|---|
| 危险品运输编号 | UN 2319 3/PG 3 |
| WGK Germany | 3 |
| 危险等级 | 3.2 |
| 包装类别 | III |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N7363 | Isolongifolene | 1 mg | 514元 | |
| 2024/01/25 | HY-N7363 | 异长叶烯 Isolongifolene | 1135-66-6 | 5mg | 1350元 |