N-乙酰-L-4-羟基脯氨酸
中文名称 | N-乙酰-L-4-羟基脯氨酸 |
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中文同义词 | N-乙酰-L-羟脯氨酸;奥沙西罗;酰羟氢吡咯酸;N-乙酰-4-羟基-L-脯氨酸;1-乙酰基-4-羟基吡咯烷羧酸;4-羟基-N-乙酰基脯氨酸;反式-1-乙酰基-4-羟基-L-脯氨酸;N-乙酰-4-羟基脯氨酸 |
英文名称 | Oxaceprol |
英文同义词 | TRANS-1-ACETYL-4-HYDROXY-L-PROLINE;N-ACETYLHYDROXY-L-PROLINE;N-ACETYL-L-HYDROXYPROLINE;N-ALPHA-ACETYL-TRANS-4-HYROXY-L-PYROLLIDINE;N-ALPHA-ACETYL-L-4-TRANS-HYDROXYPROLINE;N-ALPHA-ACETYL-L-HYROXYPROLINE;(-)-1-Acetyl-4β-hydroxy-L-proline;(4R)-1-Acetyl-4-hydroxy-L-proline |
CAS号 | 33996-33-7 |
分子式 | C7H11NO4 |
分子量 | 173.17 |
EINECS号 | 251-780-6 |
相关类别 | 生化试剂;中间体;佐芬普利钙相关中间体;氨基酸;氨基酸衍生物;医药中间体;保护氨基酸;非天然氨基酸;PYRROLE;API intermediates;Amino Acids;胺基酸;Hydroxyproline [Hyp];Peptide Synthesis;Proline Derivatives;Unnatural Amino Acid Derivatives;合成;氨基酸类 |
Mol文件 | 33996-33-7.mol |
结构式 |
N-乙酰-L-4-羟基脯氨酸 性质
熔点 | 132-133 °C (dec.)(lit.) |
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沸点 | 303.8°C (rough estimate) |
比旋光度 | -119 º (c=4 in H2O) |
密度 | 1.3346 (rough estimate) |
蒸气压 | 0Pa at 20℃ |
折射率 | 1.4490 (estimate) |
储存条件 | Sealed in dry,2-8°C |
溶解度 | 二甲基亚砜:≥32mg/mL(184.79mM) |
酸度系数(pKa) | 3.48±0.40(Predicted) |
形态 | 结晶粉末 |
颜色 | 白色 |
旋光性 (optical activity) | [α]20/D 119°, c = 4 in H2O |
Merck | 14,6903 |
BRN | 84043 |
InChIKey | BAPRUDZDYCKSOQ-RITPCOANSA-N |
LogP | -1.51 at 20℃ |
CAS 数据库 | 33996-33-7(CAS DataBase Reference) |
EPA化学物质信息 | L-Proline, 1-acetyl-4-hydroxy-, (4R)- (33996-33-7) |
Oxaceprol, at 6 mg/kg/day for 7 days, significantly reduces both the surface area and wet weight of cotton pellet granulomas, being slightly less effective than indomethacin, 3 mg/kg.
Oxaceprol (6–54 mg/kg/day) given therapeutically had no effect on the primary paw oedema response, but inhibits secondary lesions in the ears and tail.
Oxaceprol does not inhibit the synthesis of prostaglandins in vitro, but markedly inhibits neutrophil infiltration into the joints of rats with adjuvant arthritis.
Animal Model: | Male Sprague-Dawley rats. |
Dosage: | 18, 50 or 150 mg/kg. |
Administration: | Gavage daily for 15 days. |
Result: | Produced comparable inhibition of hyperalgesia to that produced by indomethacin. |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | B23767 | N-乙酰-4-羟基脯氨酸, 99% N-Acetyl-trans-4-hydroxy-L-proline, 99% | 33996-33-7 | 2g | 646元 |
2024/08/19 | B23767 | N-乙酰-4-羟基脯氨酸, 99% N-Acetyl-trans-4-hydroxy-L-proline, 99% | 33996-33-7 | 10g | 1471元 |