德伦环烷

德伦环烷

中文名称德伦环烷
中文同义词德伦环烷;化合物 T10996
英文名称DERAMCICLANE
英文同义词DERAMCICLANE;DERAMCLCLANE;N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine;N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;EGIS-3886;Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-;N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine
CAS号120444-71-5
分子式C20H31NO
分子量301.47
EINECS号
相关类别
Mol文件120444-71-5.mol
结构式德伦环烷 结构式

德伦环烷 性质

沸点375.2±25.0 °C(Predicted)
密度1.01±0.1 g/cm3(Predicted)
储存条件Store at -20°C
溶解度溶于二甲基亚砜
酸度系数(pKa)pKa 9.61±0.03(H2O t=25±0.1 I=0.1(NaCl)) (Uncertain)

德伦环烷 用途与合成方法

Deramciclane 对 5-HT2A 和 5-HT2C 受体具有高亲和力。Deramciclane 作为两种受体亚型的拮抗剂,对 5-HT2C 受体具有反向激动剂特性,无直接刺激激动剂。

5-HT 2A Receptor

5-HT 2C Receptor

Deramciclane is a novel anxiolytic agent that binds with high affinity to 5-HT 2A / 2C receptors. The interactions of Deramciclane with the serotonin 5-HT 2C receptor are characterized further using receptor phosphoinositide hydrolysis assays and receptor autoradiography. Deramciclane antagonizes 5-HT 2C receptor mediated 5-HT-stimulated phosphoinositide hydrolysis with an IC 50 value of 168 nM. Deramciclane also decreases basal phosphoinositide hydrolysis by up to 33% (EC 50 = 93 nM) in a physiological system in the choroid plexus, suggesting that Deramciclane possesses inverse agonist properties at this receptor.

Deramciclane 3 and 10 mg/kg does not change the dopamine levels significantly at any time point versus the basal level whereas 30 mg/kg of Deramciclane significantly increases the levels at 40-100 min and at 160-240 min (P<0.05). Deramciclane is a putative antiserotonergic compound that reduces 5-HT-induced phosphoinositol hydrolysis and a variety of actions caused by serotonergic agonists. The receptor binding profile of Deramciclane is rather similar to that of ritanserin. Deramciclane has a high affinity for 5-HT 2A and 5-HT 2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT 2C receptors without direct stimulatory agonist effects. Deramciclane has been shown to have anxiolytic-like activity in several animal tests.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-101630Deramciclane1 mg1590元
2024/01/25HY-101630德伦环烷
Deramciclane
120444-71-55mg3500元

德伦环烷 上下游产品信息

上游原料
"德伦环烷"相关产品信息
环烷油 (1R,2R,4R)-REL-2-甲氧基-1,7,7-三甲基二环[2.2.1]庚烷 德伦环烷 2-甲基异冰片 异龙脑 2,2-二甲基-1-苯基-1-丙醇 1-苯基-1-环己醇
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