蓟黄素
| 中文名称 | 蓟黄素 |
|---|---|
| 中文同义词 | 蓟黄素;5-羟基-2-(4-羟基苯基)-6,7-二甲氧基-4H-苯并吡喃-4-酮 |
| 英文名称 | cirsimaritin |
| 英文同义词 | 4',5-Dihydroxy-6,7-dimethoxyflavone;5-Hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one;6-Methoxygenkwanin;Scrophulein;Skrofulein;Cirsimaritin >=90% (LC/MS-ELSD);4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-;Circimaritin |
| CAS号 | 6601-62-3 |
| 分子式 | C17H14O6 |
| 分子量 | 314.29 |
| EINECS号 | |
| 相关类别 | 中药对照品;黄酮;植物提取物;Miscellaneous Natural Products |
| Mol文件 | 6601-62-3.mol |
| 结构式 |  |
蓟黄素 性质
| 熔点 | 257 °C |
|---|---|
| 沸点 | 563.6±50.0 °C(Predicted) |
| 密度 | 1.402±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 二甲基亚砜：10mM |
| 形态 | 固体 |
| 酸度系数(pKa) | 6.34±0.40(Predicted) |
| LogP | 1.970 (est) |
Cirsimaritin可以较弱的靶向结合 GABAA 受体上的苯二氮平位点，并拥有抗抑郁、抗焦虑、抗接种等活性。
Cirsimaritin significantly reduces the anxiety in mice. Cirsimaritin does not decrease by co-administration of flumazenil (2.5 mg/kg) with salvigenin, rosmanol and cirsimaritin (10 mg/kg), indicating that the high-affinity benzodiazepine binding site is not involved in the anxiolytic activity induced by these compounds.