氯毒素
| 中文名称 | 氯毒素 |
|---|---|
| 中文同义词 | 氯代毒素;氯毒素;U251MG细胞迁移抑制剂(CHLOROTOXIN);氯毒素, >97% |
| 英文名称 | CHLOROTOXIN |
| 英文同义词 | CHLOROTOXIN;CLTX;CLTX (EGYPTIAN SCORPION);H-MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-NH2;H-MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-NH2, (DISULFIDE BONDS BETWEEN CYS2 AND CYS19/CYS5 AND CYS28/CYS16 AND CYS33/CYS20 AND CYS35);H-MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-OH;MET-CYS-MET-PRO-CYS-PHE-THR-THR-ASP-HIS-GLN-MET-ALA-ARG-LYS-CYS-ASP-ASP-CYS-CYS-GLY-GLY-LYS-GLY-ARG-GLY-LYS-CYS-TYR-GLY-PRO-GLN-CYS-LEU-CYS-ARG-NH2;CHLOROTOXIN, RECOMBINANT, EXPRESSED |
| CAS号 | 163515-35-3 |
| 分子式 | C158H249N53O47S11 |
| 分子量 | 3995.70956 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂;目录多肽;Chloride Channel Modulators;Voltage-gated Ion Channels;Monovalent Ion Channels |
| Mol文件 | 163515-35-3.mol |
| 结构式 |  |
氯毒素 性质
| 储存条件 | −20°C |
|---|---|
| 溶解度 | 可溶于水性缓冲液 |
| 形态 | 冻干粉 |
Target: Chloride Channel
Chlorotoxin (Chlorotoxin) preferentially binds to tumor cells and has been harnessed to develop an imaging agent to help visualize tumors during surgical resection. In addition, chlorotoxin has potential as a vehicle to deliver anti-cancer drugs specifically to cancer cells. Chlorotoxin is shown to bind glioma cells, but is unable to bind normal rat astrocytes and Te671, a human rhabdomyosarcoma cell line. Chlorotoxin inhibits the migration of U251MG (glioma) cells, with an IC 50 of 600 nM. Chlorotoxin binds to glioma cells is specific and involves high affinity (K d =4.2 nM) and low affinity (K d =660 nM) binding sites.Small conductance chloride channels are shown to be potently blocked by Chlorotoxin. Chlorotoxin has been used as a general pharmacological tool to investigate the function of chloride channels.
Chlorotoxin shows insecticidal activity on insects and other invertebrates. After the administration of I-Chlorotoxin to tumor-bearing mice, the peptides accumulated within the tumor.Chlorotoxin selectively accumulates in the brain of tumor-bearing mice with calculated brain: muscle ratios of 36.4% of injected dose/g (ID/g), as compared to 12.4%ID/g in control animals.
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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