酒石酸噻吩嘧啶
| 中文名称 | 酒石酸噻吩嘧啶 |
|---|---|
| 中文同义词 | 酒石酸噻嘧啶;酒石酸噻吩嘧啶;酒石酸赛嘧啶 |
| 英文名称 | PYRANTEL TARTRATE SALT |
| 英文同义词 | 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-pyrimidin(e)-pyrimidintartrate;cp10423-18;pyrantel hydrogen tartrate;Pyrantel Tartate;(E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidine tartrate (1:1);PYRANTEL TARTRATE SALT;Pyrantel (+)-tartrate salt,1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine;1-METHYL-2-[2-(2-THIENYL)ETHENYL]-1,4,5,6-TETRAHYDROPYRIMIDINE TARTRATE SALT |
| CAS号 | 33401-94-4 |
| 分子式 | C15H20N2O6S |
| 分子量 | 356.39 |
| EINECS号 | 251-501-8 |
| 相关类别 | 酒石酸噻吩嘧啶;小分子抑制剂;原料药;化合物;医药原料;化工原料 |
| Mol文件 | 33401-94-4.mol |
| 结构式 |  |
酒石酸噻吩嘧啶 性质
| 熔点 | 148-150° |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | H2O中可溶 4.0ML，透明，无色至淡黄色或棕褐色（溶剂：200 mg 加 4.0 mL） |
Pyrantel tartrate，一种四氢嘧啶光谱驱虫药，是烟碱乙酰胆碱受体 (nAChR) 激动剂。Pyrantel tartrate 可引起寄生虫的痉挛性肌肉麻痹。Pyrantel tartrate 可用于胃肠道线虫感染的研究。
Pyrantel induces
Ascaris suum
muscle contraction, with a pEC
50
of 7.24.
Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle.
Pyrantel (72 h) inhibits the survival of
Ancylostoma ceylanicum
,
Necator americanus
and
Trichuris muris
on the third-stage larvae (IC
50
s=90.9, 2.0, and 95.5 µg/mL, respectively) and adult worms (IC
50
s=>100, 7.6, and 34.1 µg/mL, respectively).
Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum -infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.
安全信息
| 提供商 | 语言 |
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英文
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